Christoph N Seubert, MD, PhD, DABNM
Professor Of Anesthesiology And Neurosurgery
Business Phone: (352) 273-8960
Business Email: email@example.com
About Christoph N Seubert
Dr. Seubert is a Professor of Anesthesiology and Neurosurgery and the Chief of the Division of Neuroanesthesia at the University of Florida. He received his medical degree from Julius-Maximilians-Universität in Würzburg, Germany, and his Ph.D. from Albert-Ludwigs-Universität in Freiburg, Germany.
Dr. Seubert completed his residency in anesthesiology at the University of Heidelberg in Heidelberg, Germany. Additionally, he completed an anesthesiology residency, as well as a fellowship in cardiothoracic and vascular anesthesia, here at the University of Florida. His clinical interests are in anesthesia for neurosurgical procedures and intraoperative neurophysiologic monitoring.
PHA7980 Research for Doctoral Dissertation
AnesthesiologyAmerican Board of Anesthesiology
Pediatric AnesthesiologyAmerican Board of Anethesiology
Open Researcher and Contributor ID (ORCID)
Enhanced recovery after surgery (ERAS) for open transforaminal lumbar interbody fusion: a retrospective propensity-matched cohort study
The Spine Journal. 22(3):399-410 [DOI] 10.1016/j.spinee.2021.10.007. [PMID] 34687905.
Enhanced recovery after surgery (ERAS) improves return of physiological function in frail patients undergoing one- to two-level TLIFs: an observational retrospective cohort study
The Spine Journal. 22(9):1513-1522 [DOI] 10.1016/j.spinee.2022.04.007. [PMID] 35447326.
Best Practices in Facial Nerve Monitoring
The Laryngoscope. 131(S4) [DOI] 10.1002/lary.29459.
Frailty Assessment and Prehabilitation Before Complex Spine Surgery in Patients With Degenerative Spine Disease: A Narrative Review.
Journal of neurosurgical anesthesiology. [DOI] 10.1097/ANA.0000000000000787. [PMID] 34354024.
Letter to the Editor. What are the odds: worse outcomes with IONM?
Journal of neurosurgery. 136(1):321-322 [DOI] 10.3171/2021.4.JNS21918. [PMID] 34479195.
Methadone and a Clinical Pathway in Adolescent Idiopathic Scoliosis Surgery: A Historically Controlled Study
Global Spine Journal. 10(7):837-843 [DOI] 10.1177/2192568219878135. [PMID] 32905725.
Neuroanesthesiologists as interoperative neurophysiologists: a collaborative cognitive apprenticeship model of training in a community of clinical practice.
Journal of clinical monitoring and computing. 34(2):325-330 [DOI] 10.1007/s10877-019-00304-0. [PMID] 30955161.
Transcranial Motor Evoked Potential Monitoring in a Patient With a Deep Brain Stimulator: A Case Report
Journal of Clinical Neurophysiology. 38(1):e1-e4 [DOI] 10.1097/WNP.0000000000000705. [PMID] 32501949.
Acceptance of a propofol and remifentanil infusion dosing algorithm to optimize postoperative emergence and analgesia.
Journal of clinical monitoring and computing. 33(6):953-957 [DOI] 10.1007/s10877-019-00295-y. [PMID] 30868345.
Correction to: Is the new ASNM intraoperative neuromonitoring supervision “guideline” a trustworthy guideline? A commentary.
Journal of clinical monitoring and computing. 33(2):191-192 [DOI] 10.1007/s10877-019-00266-3. [PMID] 30778916.
Intergenerational Effects of Sevoflurane in Young Adult Rats.
Anesthesiology. 131(5):1092-1109 [DOI] 10.1097/ALN.0000000000002920. [PMID] 31517640.
Is the new ASNM intraoperative neuromonitoring supervision “guideline” a trustworthy guideline? A commentary.
Journal of clinical monitoring and computing. 33(2):185-190 [DOI] 10.1007/s10877-018-00242-3. [PMID] 30612285.
Proof of principle: Preoperative cognitive reserve and brain integrity predicts intra-individual variability in processed EEG (Bispectral Index Monitor) during general anesthesia.
PloS one. 14(5) [DOI] 10.1371/journal.pone.0216209. [PMID] 31120896.
Effects of combined brief etomidate anesthesia and postnatal stress on amygdala expression of Cl- cotransporters and corticotropin-releasing hormone and alcohol intake in adult rats.
Neuroscience letters. 685:83-89 [DOI] 10.1016/j.neulet.2018.08.019. [PMID] 30125644.
Not Everything That Shakes Is a Seizure: A Case Report
A&A practice. 10(10):267-271 [DOI] 10.1213/XAA.0000000000000682. [PMID] 29293485.
Role of epigenetic mechanisms in transmitting the effects of neonatal sevoflurane exposure to the next generation of male, but not female, rats.
British journal of anaesthesia. 121(2):406-416 [DOI] 10.1016/j.bja.2018.04.034. [PMID] 30032879.
Simultaneous Retrodialysis by Calibrator for Rapid In Vivo Recovery Determination in Target Site Microdialysis.
Journal of pharmaceutical sciences. 107(8):2259-2265 [DOI] 10.1016/j.xphs.2018.04.021. [PMID] 29715477.
Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 109S:S2-S8 [DOI] 10.1016/j.ejps.2017.05.025. [PMID] 28533143.
Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.
Psychoneuroendocrinology. 81:96-104 [DOI] 10.1016/j.psyneuen.2017.04.001. [PMID] 28433802.
A Prospective Time-Series Quality Improvement Trial of a Standardized Analgesia Protocol to Reduce Postoperative Pain Among Neurosurgery Patients
Journal of Neurosurgery. 125(6):1523-1532 [DOI] 10.3171/2015.10.JNS15698.
Neurophysiological monitoring and spinal cord integrity.
Best practice & research. Clinical anaesthesiology. 30(1):53-68 [DOI] 10.1016/j.bpa.2015.11.006. [PMID] 27036603.
Propofol, but not etomidate, increases corticosterone levels and induces long-term alteration in hippocampal synaptic activity in neonatal rats.
Neuroscience letters. 618:1-5 [DOI] 10.1016/j.neulet.2016.02.045. [PMID] 26923669.
Role of Steroids in Hyperexcitatory Adverse and Anesthetic Effects of Sevoflurane in Neonatal Rats.
Neuroendocrinology. 103(5):440-51 [DOI] 10.1159/000437267. [PMID] 26159049.
Anesthesia with sevoflurane in neonatal rats: Developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl(-) importer antagonists.
Psychoneuroendocrinology. 60:173-81 [DOI] 10.1016/j.psyneuen.2015.06.016. [PMID] 26150359.
Propofol-induced electroencephalographic seizures in neonatal rats: the role of corticosteroids and γ-aminobutyric acid type A receptor-mediated excitation.
Anesthesia and analgesia. 120(2):433-9 [DOI] 10.1213/ANE.0000000000000529. [PMID] 25390279.
Prospective Pilot Investigation: Presurgical Depressive Symptom Severity and Anesthesia Response in Women Undergoing Surgery for Gynecologic Mass Removal.
International journal of behavioral medicine. 22(4):521-9 [DOI] 10.1007/s12529-014-9451-1. [PMID] 25421878.
Endocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats.
Anesthesiology. 121(5):1010-7 [DOI] 10.1097/ALN.0000000000000366. [PMID] 24992523.
Clinical Implications of Bilirubin-Associated Neuroprotection and Neurotoxicity.
International journal of clinical anesthesiology. 1(2) [PMID] 29911128.
Developmental effects of neonatal isoflurane and sevoflurane exposure in rats.
Anesthesiology. 119(2):358-64 [DOI] 10.1097/ALN.0b013e318291c04e. [PMID] 23619170.
Developmental Effects of Sevoflurane in Rats May Involve the Anesthetic-Caused Dysregulation of the Hypothalamic-Pituitary-Adrenal (Hpa) Axis
Anesthesia and Analgesia. 116(1)
Electroencephalogram effects of armodafinil: comparison with behavioral alertness.
Journal of clinical pharmacology. 53(10):1058-71 [DOI] 10.1002/jcph.143. [PMID] 23913585.
Pharmacokinetic-Pharmacodynamic Modeling of Armodafinil: Effects On Alertness and Electroen-Cephalogram of Sleep Deprived Adults
Clinical Pharmacology & Therapeutics. 91:S7-S8
Roles of aldosterone and oxytocin in abnormalities caused by sevoflurane anesthesia in neonatal rats.
Anesthesiology. 117(4):791-800 [PMID] 22854980.
Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.
International journal of antimicrobial agents. 40(1):51-4 [DOI] 10.1016/j.ijantimicag.2012.03.006. [PMID] 22584101.
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
Amino acids. 40(4):1151-8 [DOI] 10.1007/s00726-010-0739-4. [PMID] 20839013.
Population Pharmacokinetics and Pharmacodynamics of Armodafinil: Effects On Electroencephalogram and Alertness of Sleep Deprived Adults
Transient bilateral brainstem dysfunction caused by topical administration of papaverine.
Journal of neurosurgery. [PMID] 21721877.
Bumetanide alleviates epileptogenic and neurotoxic effects of sevoflurane in neonatal rat brain.
Anesthesiology. 112(3):567-75 [DOI] 10.1097/ALN.0b013e3181cf9138. [PMID] 20124973.
3,5-Dibromo-L-Phenylalanine Depresses Pentylenetetrazole-Induced Seizures and Reduces Neurological and Sensorimotor Gating Deficits Caused By Stroke
Journal of the Neurological Sciences. 285
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
British journal of pharmacology. 158(8):2005-13 [PMID] 20050189.
Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.
Antimicrobial agents and chemotherapy. 53(7):2773-6 [DOI] 10.1128/AAC.01409-08. [PMID] 19364847.
Anesthesia in Space – Pk/Pd Modeling of Propofol in Simulated Microgravity
Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders.
Recent patents on CNS drug discovery. 1(3):261-70 [PMID] 18221208.
Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine.
Molecular pharmacology. 67(5):1648-54 [PMID] 15687225.
Impaired glutamatergic synaptic transmission in the PKU brain.
Molecular genetics and metabolism. 86 Suppl 1:S34-42 [PMID] 16153867.
Long-term changes in glutamatergic synaptic transmission in phenylketonuria.
Brain : a journal of neurology. 128(Pt 2):300-7 [PMID] 15634735.
Mass spectral fragmentation of the intravenous anesthetic propofol and structurally related phenols.
Journal of the American Society for Mass Spectrometry. 16(6):814-24 [PMID] 15907697.
A new method for the quantitation of propofol in human plasma: efficient solid-phase extraction and liquid chromatography/APCI-triple quadrupole mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 810(2):291-6 [PMID] 15380727.
Bispectral index decline caused by neuromuscular blockade.
Anesthesia and analgesia. 98(3):871; author reply 873-4 [PMID] 14980957.
Neuroprotective action of halogenated derivatives of L-phenylalanine.
Stroke. 35(5):1192-6 [PMID] 15073406.
Pluronic microemulsions as nanoreservoirs for extraction of bupivacaine from normal saline.
Journal of the American Chemical Society. 126(16):5108-12 [PMID] 15099093.
The effect of body inclination during prone positioning on intraocular pressure in awake volunteers: a comparison of two operating tables.
Anesthesia and analgesia. 99(4):1152-1158 [DOI] 10.1213/01.ANE.0000130851.37039.50. [PMID] 15385367.
L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses.
Journal of neuroscience research. 72(1):116-24 [PMID] 12645085.
Transient paraplegia after stent grafting of a descending thoracic aortic aneurysm treated with cerebrospinal fluid drainage.
Journal of clinical anesthesia. 15(1):59-63 [PMID] 12657411.
Contribution of I(K,ADO) to the negative dromotropic effect of adenosine.
Basic research in cardiology. 97(4):286-94 [PMID] 12111038.
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism.
Basic research in cardiology. 97(4):295-304 [PMID] 12111039.
Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria.
Molecular psychiatry. 7(4):359-67 [PMID] 11986979.
Venous air embolism during changes in patient position or ventilation: an etiology for postoperative cardiovascular collapse?
Anesthesia and analgesia. 95(5):1465-6; author reply 1466 [PMID] 12401655.
Structure-activity relationships and electrophysiological effects of short-acting amiodarone homologs in guinea pig isolated heart.
The Journal of pharmacology and experimental therapeutics. 297(1):260-6 [PMID] 11259553.
Antagonism of the positive dromotropic effect of isoproterenol by adenosine: role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G.
Journal of molecular and cellular cardiology. 32(9):1609-19 [PMID] 10966824.
Midazolam selectively potentiates the A(2A) – but not A1- receptor–mediated effects of adenosine: role of nucleoside transport inhibition and clinical implications.
Anesthesiology. 92(2):567-77 [PMID] 10691246.
Role of A(2A)-adenosine receptor activation for ATP-mediated coronary vasodilation in guinea-pig isolated heart.
British journal of pharmacology. 130(5):1065-75 [PMID] 10882391.
Cardiac arrest after uncomplicated right upper lobectomy.
Journal of cardiothoracic and vascular anesthesia. 13(1):105-6 [PMID] 10069295.
Ionic mechanisms mediating the differential effects of methohexital and thiopental on action potential duration in guinea pig and rabbit isolated ventricular myocytes.
Anesthesiology. 90(1):156-64 [PMID] 9915324.
Presence of an echogenic mass on the pulmonary valve and right ventricular outflow tract.
Journal of cardiothoracic and vascular anesthesia. 13(6):789-90 [PMID] 10622667.
[Anesthesia in carotid surgery].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. 29(4):195-202 [PMID] 7981342.
Nov 2021 ACTIVE
Preoperative sleep spindles and delirium in Alzheimer's Disease
Funding: ALZHEIMERS ASSO
Fellowship – Cardiovascular Anesthesia2000 · University of Florida
Residency – Anesthesiology1998 · University of Florida
Residency – Internal Medicine1995 · Memorial Medical Center
Medical Degree1991 · Albert-Ludwigs Universitat
PhD1991 · Julius-Maximilians University
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