Christoph N Seubert

Christoph N Seubert, MD, PhD, DABNM

Professor Of Anesthesiology And Neurosurgery

Department: MD-ANESTHESIOLOGY-GENERAL
Business Phone: (352) 273-8960
Business Email: cseubert@anest.ufl.edu

About Christoph N Seubert

Dr. Seubert is a Professor of Anesthesiology and Neurosurgery and the Chief of the Division of Neuroanesthesia at the University of Florida. He received his medical degree from Julius-Maximilians-Universität in Würzburg, Germany, and his Ph.D. from Albert-Ludwigs-Universität in Freiburg, Germany.

Dr. Seubert completed his residency in anesthesiology at the University of Heidelberg in Heidelberg, Germany. Additionally, he completed an anesthesiology residency, as well as a fellowship in cardiothoracic and vascular anesthesia, here at the University of Florida. His clinical interests are in anesthesia for neurosurgical procedures and intraoperative neurophysiologic monitoring.

Board Certifications

  • Anesthesiology
    American Board of Anesthesiology
  • Pediatric Anesthesiology
    American Board of Anethesiology

Clinical Profile

Specialties
  • Anesthesiology

Publications

2021
Best Practices in Facial Nerve Monitoring.
The Laryngoscope. 131 Suppl 4:S1-S42 [DOI] 10.1002/lary.29459. [PMID] 33729584.
2020
Neuroanesthesiologists as interoperative neurophysiologists: a collaborative cognitive apprenticeship model of training in a community of clinical practice.
Journal of clinical monitoring and computing. 34(2):325-330 [DOI] 10.1007/s10877-019-00304-0. [PMID] 30955161.
2020
Transcranial Motor Evoked Potential Monitoring in a Patient With a Deep Brain Stimulator: A Case Report
Journal of Clinical Neurophysiology. 38(1):e1-e4 [DOI] 10.1097/WNP.0000000000000705. [PMID] 32501949.
2019
Acceptance of a propofol and remifentanil infusion dosing algorithm to optimize postoperative emergence and analgesia.
Journal of clinical monitoring and computing. 33(6):953-957 [DOI] 10.1007/s10877-019-00295-y. [PMID] 30868345.
2019
Correction to: Is the new ASNM intraoperative neuromonitoring supervision “guideline” a trustworthy guideline? A commentary.
Journal of clinical monitoring and computing. 33(2):191-192 [DOI] 10.1007/s10877-019-00266-3. [PMID] 30778916.
2019
Intergenerational Effects of Sevoflurane in Young Adult Rats.
Anesthesiology. 131(5):1092-1109 [DOI] 10.1097/ALN.0000000000002920. [PMID] 31517640.
2019
Is the new ASNM intraoperative neuromonitoring supervision “guideline” a trustworthy guideline? A commentary.
Journal of clinical monitoring and computing. 33(2):185-190 [DOI] 10.1007/s10877-018-00242-3. [PMID] 30612285.
2019
Proof of principle: Preoperative cognitive reserve and brain integrity predicts intra-individual variability in processed EEG (Bispectral Index Monitor) during general anesthesia.
PloS one. 14(5) [DOI] 10.1371/journal.pone.0216209. [PMID] 31120896.
2018
Effects of combined brief etomidate anesthesia and postnatal stress on amygdala expression of Cl- cotransporters and corticotropin-releasing hormone and alcohol intake in adult rats.
Neuroscience letters. 685:83-89 [DOI] 10.1016/j.neulet.2018.08.019. [PMID] 30125644.
2018
Not Everything That Shakes Is a Seizure: A Case Report
A&A practice. 10(10):267-271 [DOI] 10.1213/XAA.0000000000000682. [PMID] 29293485.
2018
Role of epigenetic mechanisms in transmitting the effects of neonatal sevoflurane exposure to the next generation of male, but not female, rats.
British journal of anaesthesia. 121(2):406-416 [DOI] 10.1016/j.bja.2018.04.034. [PMID] 30032879.
2018
Simultaneous Retrodialysis by Calibrator for Rapid In Vivo Recovery Determination in Target Site Microdialysis.
Journal of pharmaceutical sciences. 107(8):2259-2265 [DOI] 10.1016/j.xphs.2018.04.021. [PMID] 29715477.
2017
Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 109S:S2-S8 [DOI] 10.1016/j.ejps.2017.05.025. [PMID] 28533143.
2017
Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.
Psychoneuroendocrinology. 81:96-104 [DOI] 10.1016/j.psyneuen.2017.04.001. [PMID] 28433802.
2016
A Prospective Time-Series Quality Improvement Trial of a Standardized Analgesia Protocol to Reduce Postoperative Pain Among Neurosurgery Patients
Journal of Neurosurgery. 125(6):1523-1532 [DOI] 10.3171/2015.10.JNS15698.
2016
Neurophysiological monitoring and spinal cord integrity.
Best practice & research. Clinical anaesthesiology. 30(1):53-68 [DOI] 10.1016/j.bpa.2015.11.006. [PMID] 27036603.
2016
Propofol, but not etomidate, increases corticosterone levels and induces long-term alteration in hippocampal synaptic activity in neonatal rats.
Neuroscience letters. 618:1-5 [DOI] 10.1016/j.neulet.2016.02.045. [PMID] 26923669.
2016
Role of Steroids in Hyperexcitatory Adverse and Anesthetic Effects of Sevoflurane in Neonatal Rats.
Neuroendocrinology. 103(5):440-51 [DOI] 10.1159/000437267. [PMID] 26159049.
2015
Anesthesia with sevoflurane in neonatal rats: Developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl(-) importer antagonists.
Psychoneuroendocrinology. 60:173-81 [DOI] 10.1016/j.psyneuen.2015.06.016. [PMID] 26150359.
2015
Propofol-induced electroencephalographic seizures in neonatal rats: the role of corticosteroids and γ-aminobutyric acid type A receptor-mediated excitation.
Anesthesia and analgesia. 120(2):433-9 [DOI] 10.1213/ANE.0000000000000529. [PMID] 25390279.
2015
Prospective Pilot Investigation: Presurgical Depressive Symptom Severity and Anesthesia Response in Women Undergoing Surgery for Gynecologic Mass Removal.
International journal of behavioral medicine. 22(4):521-9 [DOI] 10.1007/s12529-014-9451-1. [PMID] 25421878.
2014
Endocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats.
Anesthesiology. 121(5):1010-7 [DOI] 10.1097/ALN.0000000000000366. [PMID] 24992523.
2013
Clinical Implications of Bilirubin-Associated Neuroprotection and Neurotoxicity.
International journal of clinical anesthesiology. 1(2) [PMID] 29911128.
View on: PubMed
2013
Developmental effects of neonatal isoflurane and sevoflurane exposure in rats.
Anesthesiology. 119(2):358-64 [DOI] 10.1097/ALN.0b013e318291c04e. [PMID] 23619170.
2013
Developmental Effects of Sevoflurane in Rats May Involve the Anesthetic-Caused Dysregulation of the Hypothalamic-Pituitary-Adrenal (Hpa) Axis
Anesthesia and Analgesia. 116(1)
2013
Electroencephalogram effects of armodafinil: comparison with behavioral alertness.
Journal of clinical pharmacology. 53(10):1058-71 [DOI] 10.1002/jcph.143. [PMID] 23913585.
2012
Pharmacokinetic-Pharmacodynamic Modeling of Armodafinil: Effects On Alertness and Electroen-Cephalogram of Sleep Deprived Adults
Clinical Pharmacology & Therapeutics. 91:S7-S8
2012
Roles of aldosterone and oxytocin in abnormalities caused by sevoflurane anesthesia in neonatal rats.
Anesthesiology. 117(4):791-800 [PMID] 22854980.
View on: PubMed
2012
Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.
International journal of antimicrobial agents. 40(1):51-4 [DOI] 10.1016/j.ijantimicag.2012.03.006. [PMID] 22584101.
2011
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
Amino acids. 40(4):1151-8 [DOI] 10.1007/s00726-010-0739-4. [PMID] 20839013.
2011
Population Pharmacokinetics and Pharmacodynamics of Armodafinil: Effects On Electroencephalogram and Alertness of Sleep Deprived Adults
. 51
2011
Transient bilateral brainstem dysfunction caused by topical administration of papaverine.
Journal of neurosurgery. [PMID] 21721877.
View on: PubMed
2010
Bumetanide alleviates epileptogenic and neurotoxic effects of sevoflurane in neonatal rat brain.
Anesthesiology. 112(3):567-75 [DOI] 10.1097/ALN.0b013e3181cf9138. [PMID] 20124973.
2009
3,5-Dibromo-L-Phenylalanine Depresses Pentylenetetrazole-Induced Seizures and Reduces Neurological and Sensorimotor Gating Deficits Caused By Stroke
Journal of the Neurological Sciences. 285
2009
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
British journal of pharmacology. 158(8):2005-13 [PMID] 20050189.
View on: PubMed
2009
Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.
Antimicrobial agents and chemotherapy. 53(7):2773-6 [DOI] 10.1128/AAC.01409-08. [PMID] 19364847.
2008
Anesthesia in Space – Pk/Pd Modeling of Propofol in Simulated Microgravity
. 48
2006
Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders.
Recent patents on CNS drug discovery. 1(3):261-70 [PMID] 18221208.
View on: PubMed
2005
Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine.
Molecular pharmacology. 67(5):1648-54 [PMID] 15687225.
View on: PubMed
2005
Impaired glutamatergic synaptic transmission in the PKU brain.
Molecular genetics and metabolism. 86 Suppl 1:S34-42 [PMID] 16153867.
View on: PubMed
2005
Long-term changes in glutamatergic synaptic transmission in phenylketonuria.
Brain : a journal of neurology. 128(Pt 2):300-7 [PMID] 15634735.
View on: PubMed
2005
Mass spectral fragmentation of the intravenous anesthetic propofol and structurally related phenols.
Journal of the American Society for Mass Spectrometry. 16(6):814-24 [PMID] 15907697.
View on: PubMed
2004
A new method for the quantitation of propofol in human plasma: efficient solid-phase extraction and liquid chromatography/APCI-triple quadrupole mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 810(2):291-6 [PMID] 15380727.
View on: PubMed
2004
Bispectral index decline caused by neuromuscular blockade.
Anesthesia and analgesia. 98(3):871; author reply 873-4 [PMID] 14980957.
View on: PubMed
2004
Neuroprotective action of halogenated derivatives of L-phenylalanine.
Stroke. 35(5):1192-6 [PMID] 15073406.
View on: PubMed
2004
Pluronic microemulsions as nanoreservoirs for extraction of bupivacaine from normal saline.
Journal of the American Chemical Society. 126(16):5108-12 [PMID] 15099093.
View on: PubMed
2004
The effect of body inclination during prone positioning on intraocular pressure in awake volunteers: a comparison of two operating tables.
Anesthesia and analgesia. 99(4):1152-8, table of contents [PMID] 15385367.
View on: PubMed
2003
L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses.
Journal of neuroscience research. 72(1):116-24 [PMID] 12645085.
View on: PubMed
2003
Transient paraplegia after stent grafting of a descending thoracic aortic aneurysm treated with cerebrospinal fluid drainage.
Journal of clinical anesthesia. 15(1):59-63 [PMID] 12657411.
View on: PubMed
2002
Contribution of I(K,ADO) to the negative dromotropic effect of adenosine.
Basic research in cardiology. 97(4):286-94 [PMID] 12111038.
View on: PubMed
2002
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism.
Basic research in cardiology. 97(4):295-304 [PMID] 12111039.
View on: PubMed
2002
Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria.
Molecular psychiatry. 7(4):359-67 [PMID] 11986979.
View on: PubMed
2002
Venous air embolism during changes in patient position or ventilation: an etiology for postoperative cardiovascular collapse?
Anesthesia and analgesia. 95(5):1465-6; author reply 1466 [PMID] 12401655.
View on: PubMed
2001
Structure-activity relationships and electrophysiological effects of short-acting amiodarone homologs in guinea pig isolated heart.
The Journal of pharmacology and experimental therapeutics. 297(1):260-6 [PMID] 11259553.
View on: PubMed
2000
Antagonism of the positive dromotropic effect of isoproterenol by adenosine: role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G.
Journal of molecular and cellular cardiology. 32(9):1609-19 [PMID] 10966824.
View on: PubMed
2000
Midazolam selectively potentiates the A(2A) – but not A1- receptor–mediated effects of adenosine: role of nucleoside transport inhibition and clinical implications.
Anesthesiology. 92(2):567-77 [PMID] 10691246.
View on: PubMed
2000
Role of A(2A)-adenosine receptor activation for ATP-mediated coronary vasodilation in guinea-pig isolated heart.
British journal of pharmacology. 130(5):1065-75 [PMID] 10882391.
View on: PubMed
1999
Cardiac arrest after uncomplicated right upper lobectomy.
Journal of cardiothoracic and vascular anesthesia. 13(1):105-6 [PMID] 10069295.
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1999
Ionic mechanisms mediating the differential effects of methohexital and thiopental on action potential duration in guinea pig and rabbit isolated ventricular myocytes.
Anesthesiology. 90(1):156-64 [PMID] 9915324.
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1999
Presence of an echogenic mass on the pulmonary valve and right ventricular outflow tract.
Journal of cardiothoracic and vascular anesthesia. 13(6):789-90 [PMID] 10622667.
View on: PubMed
1994
[Anesthesia in carotid surgery].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. 29(4):195-202 [PMID] 7981342.
View on: PubMed

Patents

Published January 2007
Methods and Materials for Treating Mental Illness
#US-2008-0096870-A1

Education

Fellowship – Cardiovascular Anesthesia
2000 · University of Florida
Residency – Anesthesiology
1998 · University of Florida
Residency – Internal Medicine
1995 · Memorial Medical Center
Medical Degree
1991 · Albert-Ludwigs Universitat
PhD
1991 · Julius-Maximilians University

Teaching Profile

Courses Taught
2018
PHA7980 Research for Doctoral Dissertation

Contact Details

Phones:
Business:
(352) 273-8960
Emails: