Donn M Dennis

Donn M Dennis, MD, FAHA

Emeritus Professor Of Anesthesiology

Department: MD-ANESTHESIOLOGY-GENERAL
Business Phone: (352) 273-6786
Business Email: ddennis@anest.ufl.edu

About Donn M Dennis

Donn Dennis, MD, serves as The Joachim S. Gravenstein, MD, Endowed Professor of Anesthesiology at the University of Florida, College of Medicine. He is the Director of Nanomedicine and Co-Director for the State of Florida Center of Excellence in Nano-Bio Sensing, as well as Chief Science Officer and Vice President of Scientific Affairs, Xhale, Inc.

Dr. Dennis received his MD from the University of Michigan. He completed his internship in the Translational Program at William Beaumont Hospital and his residency and American Heart Association Fellowship in Cardiovascular Pharmacology and Electrophysiology at the University of Florida.

As an innovator, Dr. Dennis has a long history of honors and awards. In 2012, Dr. Dennis received the distinction of Charter Fellow for the National Academy of Inventors. He is the co-inventor of intellectual property, HyGreen™, which received numerous awards, including the New Product Innovation Award in Infection Control by Frost and Sullivan and the 2010 Medical Design Excellence Award. HyGreen™ was featured in Popular Science, Best of What’s New in 2009: Top Tech Awards, and the 100 Best Innovations of the Year.

Dr. Dennis has held committee positions with innumerable societies, such as the Committee on Research and the Committee on Scientific Papers for the American Society of Anesthesiologists. He was also the Chairman of their Sub-Committee on Experimental Circulation in 1995. Dr. Dennis is currently on the Board of Directors for the I. Heermann Anesthesia Foundation, and on the Science Advisory Board for the University of Florida’s Institute for Nanotechnology. He has also been a consultant to 11 pharmaceutical and venture capital companies.

Publications

2020
AAPM Virtual Issue on Innovation and Technology
Pain Medicine. 21(4) [DOI] 10.1093/pm/pnaa031. [PMID] 32096541.
2014
Feasibility and accuracy of nasal alar pulse oximetry.
British journal of anaesthesia. 112(6):1109-14 [DOI] 10.1093/bja/aeu095. [PMID] 24736392.
2014
Nasal Alar Blood Flow Is Maintained With Occlusion of the Facial And/Or Ophthalmic Arteries
Critical Care Medicine. 42(12, S)
2013
A novel breath test to directly measure use of vaginal gel and condoms.
AIDS and behavior. 17(6):2211-21 [DOI] 10.1007/s10461-012-0390-z. [PMID] 23321948.
2013
Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels.
Journal of clinical pharmacology. 53(1):103-11 [DOI] 10.1177/0091270011434157. [PMID] 23400750.
2013
Oral adherence monitoring using a breath test to supplement highly active antiretroviral therapy.
AIDS and behavior. 17(1):298-306 [DOI] 10.1007/s10461-012-0318-7. [PMID] 23001413.
2013
Selection of an aptamer antidote to the anticoagulant drug bivalirudin.
PloS one. 8(3) [DOI] 10.1371/journal.pone.0057341. [PMID] 23483901.
2012
Pharmacokinetic Analysis of Two Flavorants Used in a Novel Breath-Based System (Smart (Tm)) Designed To Assess Use of Vaginally Applied Products.
Clinical Pharmacology & Therapeutics. 91:S67-S68
2011
Measurement of ethanol in gaseous breath using a miniature gas chromatograph.
Journal of analytical toxicology. 35(3):134-42 [PMID] 21439148.
View on: PubMed
2010
Engineering dendritic aptamer assemblies as superior inhibitors of protein function.
Chemistry, an Asian journal. 5(1):56-9 [DOI] 10.1002/asia.200900421. [PMID] 19967736.
2010
Thromboelastographic and pharmacokinetic profiles of micro- and macro-emulsions of propofol in swine.
Biopharmaceutics & drug disposition. 31(5-6):269-77 [DOI] 10.1002/bdd.709. [PMID] 20578214.
2009
Effect of tecarfarin, a novel vitamin K epoxide reductase inhibitor, on coagulation in beagle dogs.
British journal of pharmacology. 158(6):1536-47 [DOI] 10.1111/j.1476-5381.2009.00420.x. [PMID] 19845677.
2008
C-Erbb-2 Sensing Using Algan/Gan High Electron Mobility Transistors for Breast Cancer Detection
Applied Physics Letters. 92(19) [DOI] 10.1063/1.2926656.
2008
Co(2) Detection Using Polyethylenimine/Starch Functionalized Algan/Gan High Electron Mobility Transistors
Applied Physics Letters. 92(23) [DOI] 10.1063/1.2937126.
2008
Detection of Chloride Ions Using An Integrated Ag/Agcl Electrode With Algan/Gan High Electron Mobility Transistors
Applied Physics Letters. 92(19) [DOI] 10.1063/1.2927372.
2008
Enzyme-Based Lactic Acid Detection Using Algan/Gan High Electron Mobility Transistors With Zno Nanorods Grown On the Gate Region
Applied Physics Letters. 93(4) [DOI] 10.1063/1.2966158.
2008
Exhaled-Breath Detection Using Algan/Gan High Electron Mobility Transistors Integrated With a Peltier Element
Electrochemical and Solid State Letters. 11(3):J19-J21 [DOI] 10.1149/1.2824500.
2007
Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels.
Epilepsia. 48(6):1143-50 [PMID] 17484755.
View on: PubMed
2007
The effects of buprenorphine on fentanyl withdrawal in rats.
Psychopharmacology. 191(4):931-41 [PMID] 17211652.
View on: PubMed
2006
Anesthetic properties of a propofol microemulsion in dogs.
Anesthesia and analgesia. 103(4):882-7 [PMID] 17000798.
View on: PubMed
2006
Fentanyl abuse and dependence: further evidence for second hand exposure hypothesis.
Journal of addictive diseases. 25(1):15-21 [PMID] 16597569.
View on: PubMed
2006
Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders.
Recent patents on CNS drug discovery. 1(3):261-70 [PMID] 18221208.
View on: PubMed
2006
Preparation and anesthetic properties of propofol microemulsions in rats.
Anesthesiology. 104(6):1184-90 [PMID] 16732089.
View on: PubMed
2006
Severe deficit in brain reward function associated with fentanyl withdrawal in rats.
Biological psychiatry. 59(5):477-80 [PMID] 16169528.
View on: PubMed
2006
Surface modification of silica core-shell nanocapsules: biomedical implications.
Biomacromolecules. 7(3):945-9 [PMID] 16529435.
View on: PubMed
2005
Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine.
Molecular pharmacology. 67(5):1648-54 [PMID] 15687225.
View on: PubMed
2005
Impaired glutamatergic synaptic transmission in the PKU brain.
Molecular genetics and metabolism. 86 Suppl 1:S34-42 [PMID] 16153867.
View on: PubMed
2005
Long-term changes in glutamatergic synaptic transmission in phenylketonuria.
Brain : a journal of neurology. 128(Pt 2):300-7 [PMID] 15634735.
View on: PubMed
2005
Mass spectral fragmentation of the intravenous anesthetic propofol and structurally related phenols.
Journal of the American Society for Mass Spectrometry. 16(6):814-24 [PMID] 15907697.
View on: PubMed
2005
Precision and bias of target controlled propofol infusion for sedation.
British journal of anaesthesia. 94(4):434-7 [PMID] 15681587.
View on: PubMed
2005
Scavenging nanoparticles: an emerging treatment for local anesthetic toxicity.
Regional anesthesia and pain medicine. 30(4):380-4 [PMID] 16032590.
View on: PubMed
2004
A new method for the quantitation of propofol in human plasma: efficient solid-phase extraction and liquid chromatography/APCI-triple quadrupole mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 810(2):291-6 [PMID] 15380727.
View on: PubMed
2004
A physiologically-based pharmacokinetic model of drug detoxification by nanoparticles.
Journal of pharmacokinetics and pharmacodynamics. 31(5):381-400 [PMID] 15669773.
View on: PubMed
2004
Neuroprotective action of halogenated derivatives of L-phenylalanine.
Stroke. 35(5):1192-6 [PMID] 15073406.
View on: PubMed
2004
Pluronic microemulsions as nanoreservoirs for extraction of bupivacaine from normal saline.
Journal of the American Chemical Society. 126(16):5108-12 [PMID] 15099093.
View on: PubMed
2004
Treatment of Local Anesthetic-Induced Cardiotoxicity Using Drug Scavenging Nanoparticles.
Nano letters. 4(4):757-759 [PMID] 26321882.
View on: PubMed
2003
Free radicals potentiate the negative dromotropic effect of adenosine in guinea pig isolated heart.
Acta cardiologica. 58(3):191-7 [PMID] 12846508.
View on: PubMed
2003
L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses.
Journal of neuroscience research. 72(1):116-24 [PMID] 12645085.
View on: PubMed
2002
Contribution of I(K,ADO) to the negative dromotropic effect of adenosine.
Basic research in cardiology. 97(4):286-94 [PMID] 12111038.
View on: PubMed
2002
Demonstration of a left atrial input to the atrioventricular node in humans.
Circulation. 106(23):2930-4 [PMID] 12460874.
View on: PubMed
2002
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism.
Basic research in cardiology. 97(4):295-304 [PMID] 12111039.
View on: PubMed
2002
Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria.
Molecular psychiatry. 7(4):359-67 [PMID] 11986979.
View on: PubMed
2001
Structure-activity relationships and electrophysiological effects of short-acting amiodarone homologs in guinea pig isolated heart.
The Journal of pharmacology and experimental therapeutics. 297(1):260-6 [PMID] 11259553.
View on: PubMed
2000
Antagonism of the positive dromotropic effect of isoproterenol by adenosine: role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G.
Journal of molecular and cellular cardiology. 32(9):1609-19 [PMID] 10966824.
View on: PubMed
2000
Midazolam selectively potentiates the A(2A) – but not A1- receptor–mediated effects of adenosine: role of nucleoside transport inhibition and clinical implications.
Anesthesiology. 92(2):567-77 [PMID] 10691246.
View on: PubMed
2000
Potent and reversible effects of ATI-2001 on atrial and atrioventricular nodal electrophysiological properties in guinea pig isolated perfused heart.
The Journal of pharmacology and experimental therapeutics. 295(2):779-85 [PMID] 11046118.
View on: PubMed
1999
Hyperkalemia enhances the effect of adenosine on IK,ADO in rabbit isolated AV nodal myocytes and on AV nodal conduction in guinea pig isolated heart.
Circulation. 99(2):312-8 [PMID] 9892600.
View on: PubMed
1999
Ionic mechanisms mediating the differential effects of methohexital and thiopental on action potential duration in guinea pig and rabbit isolated ventricular myocytes.
Anesthesiology. 90(1):156-64 [PMID] 9915324.
View on: PubMed
1998
Effects of volatile anesthetics on atrial and AV nodal electrophysiological properties in guinea pig isolated perfused heart.
Anesthesiology. 89(2):434-42 [PMID] 9710402.
View on: PubMed
1998
Irreversible binding of a carbostyril-based agonist and antagonist to the beta-adrenoceptor in DDT1 MF-2 cells and rat aorta.
British journal of pharmacology. 124(1):165-75 [PMID] 9630356.
View on: PubMed
1998
The A2A adenosine receptor mediates coronary vasodilation.
The Journal of pharmacology and experimental therapeutics. 284(3):1066-73 [PMID] 9495868.
View on: PubMed
1998
Validation of Furchgott’s method to determine agonist-dependent A1-adenosine receptor reserve in guinea-pig atrium.
British journal of pharmacology. 123(7):1425-33 [PMID] 9579739.
View on: PubMed
1997
Differential A1 adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes.
Molecular pharmacology. 52(4):683-91 [PMID] 9380032.
View on: PubMed
1997
Ionic basis of the differential effects of intravenous anesthetics on erythromycin-induced prolongation of ventricular repolarization in the guinea pig heart.
Anesthesiology. 87(5):1172-81 [PMID] 9366470.
View on: PubMed
1996
Binding of the novel nonxanthine A2A adenosine receptor antagonist [3H]SCH58261 to coronary artery membranes.
Circulation research. 79(6):1153-60 [PMID] 8943953.
View on: PubMed
1996
Effects of intravenous anesthetics on atrial wavelength and atrioventricular nodal conduction in guinea pig heart. Potential antidysrhythmic properties and clinical implications.
Anesthesiology. 85(2):393-402 [PMID] 8712456.
View on: PubMed
1996
Electrophysiological effects of a novel, short-acting and potent ester derivative of amiodarone, ATI-2001, in guinea pig isolated heart.
The Journal of pharmacology and experimental therapeutics. 277(3):1454-63 [PMID] 8667210.
View on: PubMed
1996
Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart.
Circulation. 94(10):2551-9 [PMID] 8921800.
View on: PubMed
1995
Frequency-dependent effects of propofol on atrioventricular nodal conduction in guinea pig isolated heart. Mechanism and potential antidysrhythmic properties.
Anesthesiology. 83(2):382-94; discussion 24A [PMID] 7631961.
View on: PubMed
1995
Homologous desensitization of the A1-adenosine receptor system in the guinea pig atrioventricular node.
The Journal of pharmacology and experimental therapeutics. 272(3):1024-35 [PMID] 7891312.
View on: PubMed
1993
Correlation of (-)N6-phenylisopropyladenosine blood levels with cardiac responses in the anesthetized guinea pig.
The Journal of pharmacology and experimental therapeutics. 265(2):543-50 [PMID] 8496805.
View on: PubMed

Grants

Jun 2011 – Jun 2018
Xhale:Advance Interdisciplinary R&D and Technology Transfer.
Role: Principal Investigator
Funding: **UF FOU UNRESTRICTED DONATION
Apr 2007 ACTIVE
Center of Excellence – Center for Nano-Biosensors
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS

Patents

Issued November 2018
Central Site Photoplethysmography, Medication Administration, and Safety
#10,137,245
Issued April 2018
Intelligent Drug And/Or Fluid Delivery System to Optimize Medical Treatment or Therapy Using Pharmacodynamic And/Or Pharmacokinetic Data
#9,950,112
Published August 2017
Medication Adherence Monitoring System(CON)
#US-2018-0017569-A1
Published June 2017
The Incorporation of Adherence Marker into a Capsule-Based Drug Delivery System
#US-2017-0367976-A1
Published September 2016
Improved Self Monitoring And Reporting Therapeutics, Smart®, Medication Adherence Monitoring Method, Device, Compositions of Matter And System
#US-2017-0074857-A1
Issued November 2014
Miniature Portable Gas Chromathograph
#D717,192
Published April 2014
Medication Adhearence Monitoring System
#US-2014-0364384-A1
Published March 2014
Marker Detection Method and Apparatus to Monitor Drug Compliance
#US-2014-0294675-A1
Published March 2014
Smart Solid Oral Dosage Forms
#US-201400341983-A1
Issued September 2013
Handwashing Compliance Detection System (CIP)
#8,525,666
Published December 2012
Central Site Photoplethysmography Medication Administration and Safety
#US-2013-0172759-A1
Issued July 2011
A Novel Handwashing Compliance Detection System
#7,978,083
Issued March 2011
Condensate Glucose Analyzer
#7,914,460
Issued July 2010
Handwashing Compliance Detection System
#7,755,494
Issued July 2009
Detoxification and Decontamination Using Nanotechnology Therapy (DIV)
#7,563,613
Issued July 2009
Detoxification and Decontamination Using Nanotechnology
#7,563,613
Published January 2009
Condensate Glucose Analyzer (CIP)
#20100216175
Published October 2008
Medication Adherence Monitoring System
#US-2010-0255598-A1
Published May 2007
System and Method for Real Time Diagnosis, Treatment and Therapeutic Drug Monitoring
#US-2007-0258894-A1
Issued April 2007
Microemulsions for Selective Molecular Separation
#7,202,282
Issued March 2007
Nanoparticle Delivery System
#7,195,780
Published March 2007
Drug Adherence Monitoring System
#US-2007-0224128-A1
Published January 2007
Methods and Materials for Treating Mental Illness
#US-2008-0096870-A1
Published November 2006
Materials and Methods for Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors
#2007/70088074
Published October 2006
Systems and Methods for Evluating Enzyme Competency
#20090005270
Issued May 2006
Novel Application of Nanotechnology and Sensor Technologies for In Vitro Diagnostics
#7,052,854
Issued December 2005
Detoxification and Decontamination Using Nanotechnology Therapy
#6,977,171
Issued December 2005
Novel Application of Biosensors for Diagnosis and Treatment
#6,974,706
Published December 2005
System and Method for Montitoring Health Using Exhaled Breath (CIP)
#US-2007-0167853-A1
Published April 2005
Marker Detection Method and Apparatus to Monitor Drug Compliance
#US 2005-0223459 A1
Published June 2004
Materials and Methods for Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors
#US-2004-0266851-A1
Issued October 2003
Novel Microemulsion and MIcelle Syustems for Solubilzing Drugs
#6,638,537
Published October 2003
Novel Microemulsion and Micelle Systems for Solubilizing Drugs
#US-2004-0198813-A
Issued September 2003
Novel Microemulsion and Micelle Systems for Solubilizing Drugs
#6,623,765
Issued September 2003
Materials and Methods for Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors.
#6,620,850
Published July 2003
Materials and Methods For Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors
#US-2004-0147590-A1
Published April 2003
Materials and Methods for Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors
#US-2003-0216472

Contact Details

Phones:
Business:
(352) 273-6786
Emails: