PeCAN Lab
Perioperative Cognitive Anesthesia Network

Perioperative Cognitive Anesthesia Network

Mission

To promote awareness of brain health in older adults prior to surgical procedures with anesthesia, intensify collaborative focus on brain-behavior-anesthesia interactions, and promote translation of research findings to clinical care.

PeCAN

Our Team

Catherine Price, PhD

Director of PeCAN, Departments of Clinical and Health Psychology, Neuropsychology, and Anesthesiology

Dr. Price designed her laboratory and research around two primary aims. First, to understand the relative contribution of brain white matter integrity versus subcortical gray matter structure integrity on the cognitive profiles associated with neurodegenerative subcortical diseases (e.g., small vessel vascular dementia/Alzheimer’s disease spectrum disorder, Parkinson’s disease). Second, to apply this knowledge towards more collaborative and longitudinal research examining the predictive value of these patients’ white and gray matter structure integrity on a) disease associated cognitive decline and b) vulnerability to cognitive change after elective medical interventions with anesthesia (e.g., major orthopedic surgery). Federally funded and non-profit institutions have and continue to support both of these research aims (NIA R01; NINDS R01; NINR R01; NSF; NINDS K23; NIA F-32 post-doctoral training award; Alzheimer’s Association; National Parkinson Foundation).  An important research subaim of her laboratory involves furthering appreciation for reliable and valid neuroimaging and cognitive assessment approaches for examining cognitive-structure dissociations/associations.

Collaborators

Kristin M Hamlet, Ph.D.
Department: Department of Clinical and Health Psychology

Kristin M Hamlet, Ph.D.

Clinical Assistant Professor
F. Kayser Enneking
Department: MD-ANESTHESIOLOGY-GENERAL

F. Kayser Enneking MD

Professor Of Anesthesiology And Orthopaedics And Rehabilitation; Medical Director, UF Health Presurgical Clinic
Brenda G Fahy
Department: MD-ANEST CRITICAL CARE MED

Brenda G Fahy MD, MCCM

Professor Of Anesthesiology; Associate Chair, Faculty Affairs And Professional Development; Program Director, Adult Combined Cardiothoracic Critical Care Fellowship
Marco Pahor
Department: MD-AGING / GERIATRIC RESEARCH

Marco Pahor M.D.

Professor & Founding Chair; Director, Institute On Aging
Glenn E Smith
Department: Department of Clinical and Health Psychology

Glenn E Smith Ph.D., ABPP-cn

Chair And Professor
Mingzhou Ding
Department: EG-BIOMEDICAL ENGINEERING

Mingzhou Ding

Professor
Thomas H Mareci
Department: MD-BIOCHEM / MOLECULAR BIOL

Thomas H Mareci Ph.D.

Professor
Jared J Tanner
Department: Department of Clinical and Health Psychology

Jared J Tanner Ph.D.

Research Assistant Professor
Steven T DeKosky
Department: MD-BEHAVIORAL NEUROLOGY

Steven T DeKosky MD

Deputy Director, McKnight Brain Institute; Aerts-Cosper Professor Of Alzheimer's Research; Associate Director 1Florida AD Research Center' And Professor Of Neurology & Neuroscience
Todd E Golde
Department: MD-NEUROSCIENCE-GENERAL

Todd E Golde

Professor, Director McKnight Brain Institute
Bruce D Spiess
Department: MD-ANESTHESIOLOGY-GENERAL

Bruce D Spiess MD, FAHA

Professor Of Anesthesiology; Associate Chair, Research
Cyndi Garvan
Department: MD-ANESTHESIOLOGY-GENERAL

Cyndi Garvan PhD

Statistician; Professor Of Anesthesiology
Parisa Rashidi
Department: EG-BIOMEDICAL ENGINEERING

Parisa Rashidi

Associate Professor
Patrick J Tighe
Department: MD-ANESTHESIOLOGY-GENERAL

Patrick J Tighe MD, MS

Associate Professor Of Anesthesiology; Donn M. Dennis MD Professorship In Anesthetic Innovation; Co-Director, Perioperative Cognitive Anesthesia Network; Associate Professor Of Orthopaedics And Information Systems And Operations Management
Thomas A Pearson
Department: PHHP-COM EPIDEMIOLOGY

Thomas A Pearson

PROF
Shawna Amini
Department: MD-ANESTHESIOLOGY-GENERAL

Shawna Amini MPH

Clinical Research Coord II

Our Research

PeCAN Cores

  • Clinical-Cognitive
    • To guide clinical and experimental approaches for perioperative cognitive and delirium examination, clinical cognitive diagnostic classification, and clinical participant recruitment/ retention planning.
  • Neuro-Imaging
    • To guide state-of-the-art neuro-imaging studies on participants or animal-based studies employing functional (fMRI), structural, and spectroscopy based methods within research-dedicated scanners within the Evelyn F. and William L. McKnight Brain Institute or UF Health patient oriented 3T clinical scanners.
  • Biomarker
    • To guide acquisition, and processing of perioperative and intraoperatively obtained biomarkers including CSF, plasma, total tau, phospho-tau, pNF-H, UCHL1, and inflammation markers (e.g., IL6, IL8, CRP).
  • Data Science
    • To guide the science of data integration and modeling for preoperative characteristics, intraoperative time-series data, postoperative clinically reported outcomes, and research based assessments from the adjoining cores. To provide trainee guidance on data quality control, database development, and collaboration with data scientists.
PeCAN cores graphical representation

Training

A unique component of the PeCAN program is the broader goal of interdisciplinary training for anesthesiology, neuropsychology, geriatric medicine, neuroscience, surgeons, and biomedical engineering. To this end, residents and medical students at the UF College of Medicine attend periodic lectures on the utility and administration of cognitive screeners.

Discussions include:

  • the rationale for incorporating cognitive tools into preoperative settings
  • the cognitive profile and behavioral presentation of highly prevalent neurodegenerative conditions (e.g., Alzheimer’s disease, Parkinson’s disease)

The PeCAN program is based on extensive research indicating that preoperative cognitive and brain health are risk factors for negative postoperative cognitive decline.

Contact Us

Our clinic is located within UF Health Shands Hospital:

  • 1600 SW Archer Road, Suite 1111, Gainesville, FL 32608
  • Call us at 352-594-6051 or email pecan@phhp.ufl.edu