Robert A Tokhunts

Robert A Tokhunts, PhD, MD

Assistant Professor Of Anesthesiology

Department: MD-ANEST CRITICAL CARE MED
Business Phone: (352) 273-6575
Business Email: rtokhunts@anest.ufl.edu

About Robert A Tokhunts

My name is Robert Tokhunts, PhD, MD, and I joined the UF Department of Anesthesiology in 2024 as an assistant professor in the Division of Critical Care Medicine. I was born in Armenia and left for the United States at the age of 16, following the collapse of the Soviet Union. I landed in New York City alone and without any ability to speak English.

After my arrival, I worked as a street cook for NYC festivals while I attended college. I began my college studies with several months of remedial education, learning basic math and English. I went on to graduate summa cum laude from the John Jay College of Criminal Justice at the City University of New York with a Bachelor of Science in forensic toxicology. During this time, I also published several organic chemistry papers, some as a lead author, and briefly considered a career in chemistry. However, after working as a forensic toxicologist for the Office of Chief Medical Examiner of New York City, I decided to obtain a PhD in pharmacology and toxicology from Dartmouth Medical School.

After my doctorate, I spent a few years as a visiting scientist at the Department of Surgical Oncology, University of Miami Miller School of Medicine. I then completed a postdoctoral fellowship in neuroscience under the mentorship of Solomon Snyder at the Johns Hopkins University Solomon Snyder Department of Neuroscience.

After my fellowship, I obtained a medical degree from Dartmouth Medical School and completed an anesthesiology residency at Dartmouth-Hitchcock. In retrospect, anesthesiology is where I was heading all along as the constant interplay of physiology and pharmacology was most appealing to me. While an anesthesiology resident, I started to appreciate that my understanding of the nuances of critical care made me a better anesthesiologist. As a result, I also completed a fellowship in critical care medicine at Dartmouth-Hitchcock.

Outside of medicine, my interests lie in understanding biology in all its forms. I have enjoyed the company of an African Grey parrot for over a decade now. I also enjoy saltwater and freshwater fishkeeping and chickens! I have three dogs, one of which I picked up from a street in Miami. I also enjoy other hobbies such as carpentry, house renovations, gardening, and electrical work.

Finally, what I learned from life thus far is humility, empathy, and understanding. My overall goal is to support everyone I work with in any way I can. I firmly believe that when the entire healthcare team feels valued, ultimately, the patients who rely on us at their most vulnerable times have the best outcomes.

Board Certifications

  • Anesthesiology
    American Board of Anesthesiology

Publications

2022
Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling.
Science signaling. 15(733) [DOI] 10.1126/scisignal.abh3066. [PMID] 35536885.
2020
Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2.
Molecular cell. 79(4) [DOI] 10.1016/j.molcel.2020.07.021. [PMID] 32822581.
2019
Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide.
Cell chemical biology. 26(10):1450-1460.e7 [DOI] 10.1016/j.chembiol.2019.07.006. [PMID] 31353321.
2015
Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties.
Cell reports. 10(8):1280-1287 [DOI] 10.1016/j.celrep.2015.01.058. [PMID] 25732819.
2014
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.
Molecular cell. 54(1):119-132 [DOI] 10.1016/j.molcel.2014.02.020. [PMID] 24657168.
2013
The hedgehog processing pathway is required for NSCLC growth and survival.
Oncogene. 32(18):2335-45 [DOI] 10.1038/onc.2012.243. [PMID] 22733134.
2012
Hedgehog signaling regulates bladder cancer growth and tumorigenicity.
Cancer research. 72(17):4449-58 [DOI] 10.1158/0008-5472.CAN-11-4123. [PMID] 22815529.
2011
Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity.
Cancer research. 71(13):4454-63 [DOI] 10.1158/0008-5472.CAN-10-2313. [PMID] 21565978.
2010
Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions.
American journal of physiology. Gastrointestinal and liver physiology. 299(6):G1252-65 [DOI] 10.1152/ajpgi.00512.2009. [PMID] 20847300.
2010
The full-length unprocessed hedgehog protein is an active signaling molecule.
The Journal of biological chemistry. 285(4):2562-8 [DOI] 10.1074/jbc.M109.078626. [PMID] 19920144.
2009
Selective inhibitor of proteasome’s caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.
Chemistry & biology. 16(12):1278-89 [DOI] 10.1016/j.chembiol.2009.11.015. [PMID] 20064438.
2009
Sonic hedgehog mutations identified in holoprosencephaly patients can act in a dominant negative manner.
Human genetics. 125(1):95-103 [DOI] 10.1007/s00439-008-0599-0. [PMID] 19057928.
2005
Diels-alder adducts of 3,6-dibromophencyclone with symmetrical 1,4-disubstituted-cis-2-butenes: comparisons with the adduct of phencyclone and N-benzylmaleimide, and one-dimensional and two-dimensional nuclear magnetic resonance studies and ab initio structure calculations.
Applied spectroscopy. 59(3):366-75 [PMID] 15901319.

Education

Critical Care Medicine Fellowship
2022-2023 · Dartmouth-Hitchcock Medical Center
Anesthesiology Residency
2018-2022 · Dartmouth-Hitchcock Medical Center
MD
2014-2018 · Dartmouth College Geisel School of Medicine
Post-Doc, Neuroscience Fellow
2012-2014 · Johns Hopkins School of Medicine
PhD
2006-2012 · Dartmouth College
BS
1999-2004 · City University of New York

Contact Details

Phones:
Business:
(352) 273-6575
Emails:
Addresses:
Business Street:
PO Box 100254
1345 SW Center Dr
GAINESVILLE FL 32611