Bruce D Spiess

Bruce D Spiess, MD, FAHA

Professor Of Anesthesiology; Associate Chair, Research

Department: MD-ANESTHESIOLOGY-GENERAL
Business Phone: (352) 273-8952
Business Email: bspiess@anest.ufl.edu

About Bruce D Spiess

Dr. Spiess joined us as a Professor of Anesthesiology and Associate Chair for Research. He was born to academic parents and grew up steeped in a research background, as his father was a geneticist and his mother was a biochemist. He attended Denison University in Granville, Ohio, where in 2017 he earned their highest honor, the Alumni citation, for his research work in medicine. He attended Rush Medical College in Chicago, followed by the Mayo Clinic for anesthesiology training, where he specialized in cardiothoracic anesthesiology and was chief resident.

Dr. Spiess returned to Rush for his first faculty position in 1983 and stayed until 1990. From there, he travelled to Seattle to become the Chief of Cardiothoracic Anesthesiology at the University of Washington. He eventually took the position of Vice Chairman of Anesthesiology at Virginia Commonwealth University in Richmond, where he stayed for 17 years until pursuing his present position at the University of Florida.

Dr. Spiess has focused on his research efforts on blood – its critical oxygen-carrying capacity, oxygen therapeutic pharmaceutical development (previously known as “blood substitutes”), the risks of blood transfusion, coagulation/coagulopathy, and developing monitoring technologies. His extensive work in the risks of blood transfusion has led him to be an outspoken proponent of patient blood management. He has authored over 200 peer-reviewed academic articles, more than 40 book chapters, 7 textbooks, and he has appeared on the Discovery Channel and other media. His work has been funded mostly by the U.S. Department of Defense, and he has led major conferences for the DOD, NIH, and FDA regarding critical blood issues. As it pertains to coagulation management, Dr. Spiess was the first to author research studies pertaining to the use of thromboelastography for heart surgery, and he has published extensively in that area, calling on clinicians to develop and utilize whole blood testing in conjunction with algorithms for coagulopathy treatment. He has been on the board of directors of various academic societies, including the Society for Cardiovascular Anesthesiologists as well as the boards of commercial companies.

Accomplishments

Best Doctors in America
2002-2019 · Best Doctors in America

Board Certifications

  • Anesthesiology
    American Board of Anesthesiology

Research Profile

Research into blood, blood substitutes/oxygen therapeutics, cardiopulmonary bypass, limiting blood transfusion, coagulation, carbon monoxide poisoning, traumatic brain injury and cardiac arrest

Publications

2021
Bivalirudin May Reduce the Need for Red Blood Cell Transfusion in Pediatric Cardiac Patients on Extracorporeal Membrane Oxygenation.
ASAIO journal (American Society for Artificial Internal Organs : 1992). 67(6):688-696 [DOI] 10.1097/MAT.0000000000001291. [PMID] 33031157.
2021
Case Report: Can Inhaled Adenosine Attenuate COVID-19?
Frontiers in pharmacology. 12 [DOI] 10.3389/fphar.2021.676577. [PMID] 34434105.
2021
Community-Based Production of Quality Face Masks for Personal Protection During the COVID-19 Pandemic.
American journal of medical quality : the official journal of the American College of Medical Quality. 36(1):17-21 [DOI] 10.1177/1062860620956726. [PMID] 32911956.
2021
Platelet and White Cell Reactivity to Top-Load Intravenous Perfluorocarbon Infusion in Healthy Sheep.
The Journal of surgical research. 267:342-349 [DOI] 10.1016/j.jss.2021.05.044. [PMID] 34192613.
2021
Ultrasound-guided external jugular and femoral arterial cannulation for juvenile swine.
Laboratory animals. [DOI] 10.1177/00236772211013630. [PMID] 33966502.
2020
Essential Role of Patient Blood Management in a Pandemic: A Call for Action.
Anesthesia and analgesia. 131(1):74-85 [DOI] 10.1213/ANE.0000000000004844. [PMID] 32243296.
2020
Oxygen therapeutic agents to target hypoxia in cancer treatment.
Current opinion in pharmacology. 53:146-151 [DOI] 10.1016/j.coph.2020.09.009. [PMID] 33086188.
2020
Successful bridge to lung transplantation with transcatheter aortic valve replacement.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 20(12):3658-3661 [DOI] 10.1111/ajt.16103. [PMID] 32506577.
2019
Anti-N and anti-Doa immunoglobulin G alloantibody-mediated delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease treated with eculizumab and HBOC-201: case report and review of the literature.
Transfusion. 59(6):1907-1910 [DOI] 10.1111/trf.15198. [PMID] 30768787.
2019
Invited Commentary.
The Annals of thoracic surgery. 108(6):1838-1839 [DOI] 10.1016/j.athoracsur.2019.05.018. [PMID] 31255607.
2019
Perfluorocarbon Emulsions, Platelet Counts, and Inflammation.
Shock (Augusta, Ga.). 52(1S Suppl 1):13-18 [DOI] 10.1097/SHK.0000000000001154. [PMID] 29642229.
2019
Perfluorocarbon Gas Transport: an Overview of Medical History With Yet Unrealized Potentials.
Shock (Augusta, Ga.). 52(1S Suppl 1):7-12 [DOI] 10.1097/SHK.0000000000001150. [PMID] 29677087.
2019
Platelets retain inducible alpha granule secretion by P-selectin expression but exhibit mechanical dysfunction during trauma-induced coagulopathy.
Journal of thrombosis and haemostasis : JTH. 17(5):771-781 [DOI] 10.1111/jth.14414. [PMID] 30784176.
2019
Vitamin B12 for the treatment of vasoplegia in cardiac surgery and liver transplantation: a narrative review of cases and potential biochemical mechanisms.
Canadian journal of anaesthesia = Journal canadien d'anesthesie. 66(12):1501-1513 [DOI] 10.1007/s12630-019-01449-x. [PMID] 31346957.
2018
Hydroxocobalamin for the treatment of cardiac surgery-associated vasoplegia: a case series.
Canadian journal of anaesthesia = Journal canadien d'anesthesie. 65(5):560-568 [DOI] 10.1007/s12630-017-1029-3. [PMID] 29209927.
2018
Interventional vitamin C: A strategy for attenuation of coagulopathy and inflammation in a swine multiple injuries model.
The journal of trauma and acute care surgery. 85(1S Suppl 2):S57-S67 [DOI] 10.1097/TA.0000000000001844. [PMID] 29538225.
2017
Application of Incident Command Structure to clinical trial management in the academic setting: principles and lessons learned.
Trials. 18(1) [DOI] 10.1186/s13063-016-1755-9. [PMID] 28183347.
2017
Heparin: Effects upon the Glycocalyx and Endothelial Cells.
The journal of extra-corporeal technology. 49(3):192-197 [PMID] 28979043.
View on: PubMed
2017
Liver graft preservation using perfluorocarbon improves the outcomes of simulated donation after cardiac death liver transplantation in rats.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 23(9):1171-1185 [DOI] 10.1002/lt.24806. [PMID] 28650112.
2017
Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas.
PloS one. 12(9) [DOI] 10.1371/journal.pone.0184250. [PMID] 28873460.
2016
A Comparison of a New Ultrasound-Based Whole Blood Viscoelastic Test (SEER Sonorheometry) Versus Thromboelastography in Cardiac Surgery.
Anesthesia and analgesia. 123(6):1400-1407 [PMID] 27159065.
View on: PubMed
2016
Platelets Reflect Biologic Complexity.
Anesthesiology. 124(2):265-6 [DOI] 10.1097/ALN.0000000000000960. [PMID] 26594914.
2015
A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement.
Toxicology. 334:45-58 [DOI] 10.1016/j.tox.2015.05.004. [PMID] 25997893.
2015
Clot Formation Is Associated With Fibrinogen and Platelet Forces in a Cohort of Severely Injured Emergency Department Trauma Patients.
Shock (Augusta, Ga.). 44 Suppl 1:39-44 [DOI] 10.1097/SHK.0000000000000342. [PMID] 25643013.
2015
Early hemostatic responses to trauma identified with hierarchical clustering analysis.
Journal of thrombosis and haemostasis : JTH. 13(6):978-88 [DOI] 10.1111/jth.12919. [PMID] 25816845.
2015
Editorial Comment: Recovery from Extreme Hemodilution (Hemoglobin Level of 0.6 g/dL) in Cadaveric Liver Transplantation and Management of a Jehovah’s Witness Patient with Sepsis and Profuse Bleeding After Emergency Coronary Artery Bypass Graft Surgery: Rethinking the Critical Threshold of Oxygen Delivery.
A & A case reports. 4(10):137-9 [DOI] 10.1213/XAA.0000000000000153. [PMID] 25974418.
2015
Hextend-perfluorocarbon cocktail inhibits mean arterial pressure response in a rabbit shock model.
The Journal of surgical research. 199(2):536-44 [DOI] 10.1016/j.jss.2015.04.063. [PMID] 26001673.
2015
Human factors analysis of a near-miss event: oxygen supply failure during cardiopulmonary bypass.
Journal of cardiothoracic and vascular anesthesia. 29(1):204-9 [DOI] 10.1053/j.jvca.2014.08.011. [PMID] 25481389.
2015
Preclinical evaluation of injectable reduced hydroxocobalamin as an antidote to acute carbon monoxide poisoning.
The journal of trauma and acute care surgery. 79(4 Suppl 2):S116-20 [DOI] 10.1097/TA.0000000000000740. [PMID] 26406423.
2015
Prehospital use of plasma in traumatic hemorrhage (The PUPTH Trial): study protocol for a randomised controlled trial.
Trials. 16 [DOI] 10.1186/s13063-015-0844-5. [PMID] 26220293.
2015
Report from AmSECT’s International Consortium for Evidence- Based Perfusion Consensus Statement: Minimal Criteria for Reporting Cardiopulmonary Bypass-Related Contributions to Red Blood Cell Transfusions Associated With Adult Cardiac Surgery.
The journal of extra-corporeal technology. 47(2):83-9 [PMID] 26405355.
View on: PubMed
2014
Assessment of Aspergillus-specific PCR as a screening method for invasive aspergillosis in paediatric cancer patients and allogeneic haematopoietic stem cell recipients with suspected infections.
Mycoses. 57(9):537-43 [DOI] 10.1111/myc.12192. [PMID] 24655146.
2014
CASE 4-2014: ascending aortic pseudoaneurysm repair with deep hypothermic circulatory arrest in an adult congenital heart disease patient with heparin-induced thrombocytopenia.
Journal of cardiothoracic and vascular anesthesia. 28(3):810-8 [DOI] 10.1053/j.jvca.2013.11.001. [PMID] 24656300.
2014
Effect of cold perfusion and perfluorocarbons on liver graft ischemia in a donation after cardiac death model.
The Journal of surgical research. 188(2):517-26 [DOI] 10.1016/j.jss.2014.01.045. [PMID] 24582069.
2014
Effects of perfluorocarbon emulsions on microvascular blood flow and oxygen transport in a model of severe arterial gas embolism.
The Journal of surgical research. 187(1):324-33 [DOI] 10.1016/j.jss.2013.08.011. [PMID] 24246440.
2014
Perfluorocarbon emulsion improves oxygen transport of normal and sickle cell human blood in vitro.
Journal of biomedical materials research. Part A. 102(7):2105-15 [DOI] 10.1002/jbm.a.34885. [PMID] 23894124.
2014
Performance of galactomannan, beta-d-glucan, Aspergillus lateral-flow device, conventional culture, and PCR tests with bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis.
Journal of clinical microbiology. 52(6):2039-45 [DOI] 10.1128/JCM.00467-14. [PMID] 24671798.
2014
The use of high-dose hydroxocobalamin for vasoplegic syndrome.
The Annals of thoracic surgery. 97(5):1785-6 [DOI] 10.1016/j.athoracsur.2013.08.050. [PMID] 24792267.
2013
Aspergillus PCR-based investigation of fresh tissue and effusion samples in patients with suspected invasive Aspergillosis enhances diagnostic capabilities.
Journal of clinical microbiology. 51(12):4178-85 [DOI] 10.1128/JCM.02387-13. [PMID] 24108612.
2013
Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery.
The Journal of thoracic and cardiovascular surgery. 145(3):796-803; discussion 803 [DOI] 10.1016/j.jtcvs.2012.12.041. [PMID] 23414992.
2013
Blood transfusion and infection after cardiac surgery.
The Annals of thoracic surgery. 95(6):1855-8 [DOI] 10.1016/j.athoracsur.2013.03.047. [PMID] 23706420.
2013
Patient safety in the cardiac operating room: human factors and teamwork: a scientific statement from the American Heart Association.
Circulation. 128(10):1139-69 [DOI] 10.1161/CIR.0b013e3182a38efa. [PMID] 23918255.
2013
The use of checklists as a method to reduce human error in cardiac operating rooms.
International anesthesiology clinics. 51(1):179-94 [DOI] 10.1097/AIA.0b013e31827da461. [PMID] 23282729.
2012
Aprotinin revisited.
The Journal of thoracic and cardiovascular surgery. 144(5):998-1002 [DOI] 10.1016/j.jtcvs.2012.06.035. [PMID] 22795461.
2012
Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011.
Innovations (Philadelphia, Pa.). 7(4):229-41 [DOI] 10.1097/IMI.0b013e3182747699. [PMID] 23123988.
2012
In vivo microvascular mosaics show air embolism reduction after perfluorocarbon emulsion treatment.
Microvascular research. 84(3):390-4 [DOI] 10.1016/j.mvr.2012.08.002. [PMID] 23010091.
2012
The effect of intravenous perfluorocarbon emulsions on whole-body oxygenation after severe decompression sickness.
Diving and hyperbaric medicine. 42(1):10-7 [PMID] 22437970.
View on: PubMed
2012
Use of a third-generation perfluorocarbon for preservation of rat DCD liver grafts.
The Journal of surgical research. 175(1):131-7 [DOI] 10.1016/j.jss.2011.02.046. [PMID] 21543088.
2011
Blood management-issues: the panic of coagulopathic bleeding–is there a rational approach?
The journal of extra-corporeal technology. 43(1):P58-64 [PMID] 21449242.
View on: PubMed
2011
Critical oxygen delivery: the crux of bypass with a special look at the microcirculation.
The journal of extra-corporeal technology. 43(1):P10-6 [PMID] 21449234.
View on: PubMed
2011
Human error in medicine: change in cardiac operating rooms through the FOCUS initiative.
The journal of extra-corporeal technology. 43(1):P33-8 [PMID] 21449238.
View on: PubMed
2011
Tissue oxygenation and microvascular hemodynamics in experimental arterial gas embolism.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. 38(6):537-48 [PMID] 22292259.
View on: PubMed
2010
A novel noninvasive impedance-based technique for central venous pressure measurement.
Shock (Augusta, Ga.). 33(3):269-73 [DOI] 10.1097/SHK.0b013e3181ab9b9b. [PMID] 19487978.
2010
Basic mechanisms of gas transport and past research using perfluorocarbons.
Diving and hyperbaric medicine. 40(1):23-8 [PMID] 23111835.
View on: PubMed
2010
Bring your life into FOCUS!
Anesthesia and analgesia. 110(2):283-7 [DOI] 10.1213/ANE.0b013e3181c920cc. [PMID] 20081123.
2010
Effect of the perioperative blood transfusion and blood conservation in cardiac surgery clinical practice guidelines of the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists upon clinical practices.
Anesthesia and analgesia. 111(2):316-23 [DOI] 10.1213/ANE.0b013e3181e329f1. [PMID] 20488928.
2010
Platelet transfusions: the science behind safety, risks and appropriate applications.
Best practice & research. Clinical anaesthesiology. 24(1):65-83 [PMID] 20402171.
View on: PubMed
2010
Pro: the practice of cardiac anesthesia has changed after the withdrawal of aprotinin.
Journal of cardiothoracic and vascular anesthesia. 24(5):875-8 [DOI] 10.1053/j.jvca.2010.07.009. [PMID] 20869614.
2010
The effect of the perioperative blood transfusion and blood conservation in cardiac surgery Clinical Practice Guidelines of the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists upon clinical practices.
The journal of extra-corporeal technology. 42(2):114-21 [PMID] 20648895.
View on: PubMed
2010
The potential role of perfluorocarbon emulsions in decompression illness.
Diving and hyperbaric medicine. 40(1):28-33 [PMID] 23111836.
View on: PubMed
2010
The two faces of Eve: gaseous anaesthesia and inert gas narcosis.
Diving and hyperbaric medicine. 40(2):68-77 [PMID] 23111897.
View on: PubMed
2009
A little coagulation knowledge can be dangerous!
Canadian journal of anaesthesia = Journal canadien d'anesthesie. 56(7):478-82 [DOI] 10.1007/s12630-009-9107-9. [PMID] 19440809.
2009
Effects of perfluorocarbon infusion in an anesthetized swine decompression model.
The Journal of surgical research. 153(1):83-94 [DOI] 10.1016/j.jss.2008.02.045. [PMID] 18541265.
2009
Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics.
Journal of applied physiology (Bethesda, Md. : 1985). 106(4):1444-52 [DOI] 10.1152/japplphysiol.90995.2008. [PMID] 19179651.
2009
Repair of type A dissection in a Jehovah’s Witness with prior cardiac operation.
The Annals of thoracic surgery. 87(1):289-90 [DOI] 10.1016/j.athoracsur.2008.09.072. [PMID] 19101314.
2009
Retinal angiography: noninvasive, real-time bubble assessment from the ocular fundus.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. 36(3):169-81 [PMID] 19860139.
View on: PubMed
2008
Case 1-2008. One institution’s decreasing use of aprotinin during cardiac surgery in 2006.
Journal of cardiothoracic and vascular anesthesia. 22(1):139-46 [DOI] 10.1053/j.jvca.2007.11.005. [PMID] 18249349.
2008
Perfluorocarbon emulsions improve cognitive recovery after lateral fluid percussion brain injury in rats.
Neurosurgery. 63(4):799-806; discussion 806 [DOI] 10.1227/01.NEU.0000325493.51900.53. [PMID] 18981892.
2008
Treating heparin resistance with antithrombin or fresh frozen plasma.
The Annals of thoracic surgery. 85(6):2153-60 [DOI] 10.1016/j.athoracsur.2008.02.037. [PMID] 18498854.
2007
Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial.
The Annals of thoracic surgery. 83(2):572-7 [PMID] 17257990.
View on: PubMed
2007
Comparison of whole blood interleukin-8 and plasma interleukin-8 as a predictor for sepsis in postoperative patients.
Clinica chimica acta; international journal of clinical chemistry. 378(1-2):117-21 [PMID] 17196571.
View on: PubMed
2007
Con: continuation of aspirin/clopidogrel for cardiac surgery.
Journal of cardiothoracic and vascular anesthesia. 21(4):606-9 [PMID] 17678799.
View on: PubMed
2007
Intravenous perfluorocarbon emulsion increases nitrogen washout after venous gas emboli in rabbits.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. 34(1):7-20 [PMID] 17393935.
View on: PubMed
2007
Off-pump coronary artery bypass with bivalirudin for patients with heparin-induced thrombocytopenia or antiplatelet factor four/heparin antibodies.
The Annals of thoracic surgery. 84(3):836-9 [PMID] 17720385.
View on: PubMed
2007
Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline.
The Annals of thoracic surgery. 83(5 Suppl):S27-86 [PMID] 17462454.
View on: PubMed
2007
Red cell transfusions and guidelines: a work in progress.
Hematology/oncology clinics of North America. 21(1):185-200 [PMID] 17258127.
View on: PubMed
2006
A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study.
The Journal of thoracic and cardiovascular surgery. 131(3):533-9 [PMID] 16515902.
View on: PubMed
2006
A new noninvasive method to determine central venous pressure.
Resuscitation. 70(2):238-46 [PMID] 16820258.
View on: PubMed
2006
Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: the results of the EVOLUTION-OFF study.
The Journal of thoracic and cardiovascular surgery. 131(3):686-92 [PMID] 16515924.
View on: PubMed
2006
Bivalirudin anticoagulation for a patient with hypercoagulable immune syndromes undergoing mitral valve surgery.
The Annals of thoracic surgery. 81(6):2308-10 [PMID] 16731183.
View on: PubMed
2006
Bivalirudin provides rapid, effective, and reliable anticoagulation during off-pump coronary revascularization: results of the “EVOLUTION OFF” trial.
Anesthesia and analgesia. 103(3):540-4 [PMID] 16931658.
View on: PubMed
2006
Case 1-2006: off-pump coronary artery bypass graft surgery anticoagulation with bivalirudin: a patient with heparin-induced thrombocytopenia syndrome type II and renal failure.
Journal of cardiothoracic and vascular anesthesia. 20(1):106-11 [PMID] 16458228.
View on: PubMed
2006
Developing a blood conservation program in cardiac surgery.
American journal of medical quality : the official journal of the American College of Medical Quality. 21(4):230-7 [PMID] 16849779.
View on: PubMed
2006
Full-dose aprotinin use in coronary artery bypass graft surgery: an analysis of perioperative pharmacotherapy and patient outcomes.
Anesthesia and analgesia. 103(5):1082-8 [PMID] 17056936.
View on: PubMed
2006
Molecular markers in stored kidneys using perfluorocarbon-based preservation solution: preliminary results.
Transplantation proceedings. 38(5):1243-6 [PMID] 16797273.
View on: PubMed
2006
Near infrared spectroscopy for evaluation of the trauma patient: a technology review.
Resuscitation. 68(1):27-44 [PMID] 16325319.
View on: PubMed
2006
The impact of an hematocrit of 20% during normothermic cardiopulmonary bypass for elective low risk coronary artery bypass graft surgery on oxygen delivery and clinical outcome–a randomized controlled study [ISRCTN35655335].
Critical care (London, England). 10(2) [PMID] 16606474.
View on: PubMed
2005
Assessment of hemostatic activation during cardiopulmonary bypass for coronary artery bypass grafting with bivalirudin: results of a pilot study.
The Journal of thoracic and cardiovascular surgery. 129(6):1391-4 [PMID] 15942583.
View on: PubMed
2005
Choose one: damned if you do/damned if you don’t!
Critical care medicine. 33(8):1871-4 [PMID] 16096475.
View on: PubMed
2005
Effect of perfluorocarbons on brain oxygenation and ischemic damage in an acute subdural hematoma model in rats.
Journal of neurosurgery. 103(4):724-30 [PMID] 16266056.
View on: PubMed
2005
Experimental analysis of critical oxygen delivery.
American journal of physiology. Heart and circulatory physiology. 288(3):H1071-9 [PMID] 15513959.
View on: PubMed
2005
Systemic responses to hemodilution after transfusion with stored blood and with a hemoglobin-based oxygen carrier.
Anesthesia and analgesia. 100(4):912-920 [DOI] 10.1213/01.ANE.0000146960.79532.DB. [PMID] 15781498.
2005
Update on heparin-induced thrombocytopenia and cardiovascular interventions.
Seminars in hematology. 42(3 Suppl 3):S22-7 [PMID] 16105555.
View on: PubMed
2004
Blood conservation: why bother?
Journal of cardiothoracic and vascular anesthesia. 18(4 Suppl):1S-5S [PMID] 15368197.
View on: PubMed
2004
Coagulation monitoring in the perioperative period.
International anesthesiology clinics. 42(2):55-71 [PMID] 15087741.
View on: PubMed
2004
Effectiveness of bivalirudin as a replacement for heparin during cardiopulmonary bypass in patients undergoing coronary artery bypass grafting.
The American journal of cardiology. 93(3):356-9 [PMID] 14759391.
View on: PubMed
2004
Perfluorocarbon emulsion improves cerebral oxygenation and mitochondrial function after fluid percussion brain injury in rats.
Neurosurgery. 54(5):1223-30; discussion 1230 [PMID] 15113478.
View on: PubMed
2004
Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes.
Transfusion. 44(8):1143-8 [PMID] 15265117.
View on: PubMed
2004
Risks of transfusion: outcome focus.
Transfusion. 44(12 Suppl):4S-14S [PMID] 15585000.
View on: PubMed
2004
Transfusion of blood products affects outcome in cardiac surgery.
Seminars in cardiothoracic and vascular anesthesia. 8(4):267-81 [PMID] 15583789.
View on: PubMed
2004
Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion.
Aviation, space, and environmental medicine. 75(4):301-5 [PMID] 15086118.
View on: PubMed
2003
An assessment of different filter systems for extracorporeal elimination of bivalirudin: an in vitro study.
Anesthesia and analgesia. 96(5):1316-1319 [DOI] 10.1213/01.ANE.0000057605.61063.55. [PMID] 12707125.
2003
Bivalirudin monitored with the ecarin clotting time for anticoagulation during cardiopulmonary bypass.
Anesthesia and analgesia. 96(2):383-6, table of contents [PMID] 12538181.
View on: PubMed
2003
Bivalirudin, thrombin and platelets: clinical implications and future directions.
The Journal of invasive cardiology. Suppl:2-15 [PMID] 23570139.
View on: PubMed
2003
Current status of antifibrinolytics in cardiopulmonary bypass and elective deep hypothermic circulatory arrest.
Anesthesiology clinics of North America. 21(3):527-51. viii [PMID] 14562564.
View on: PubMed
2003
Onset of force development as a marker of thrombin generation in whole blood: the thrombin generation time (TGT).
Journal of thrombosis and haemostasis : JTH. 1(9):1977-83 [PMID] 12941040.
View on: PubMed
2002
Blood transfusion for cardiopulmonary bypass: the need to answer a basic question.
Journal of cardiothoracic and vascular anesthesia. 16(5):535-8 [PMID] 12407601.
View on: PubMed
2002
Equivalence of bioimpedance and thermodilution in measuring cardiac index after cardiac surgery.
Journal of cardiothoracic and vascular anesthesia. 16(1):8-14 [PMID] 11854871.
View on: PubMed
2001
Blood transfusion: the silent epidemic.
The Annals of thoracic surgery. 72(5):S1832-7 [PMID] 11722117.
View on: PubMed
2001
Case 7–2001. Management during cardiopulmonary bypass of patients with presumed fish allergy.
Journal of cardiothoracic and vascular anesthesia. 15(4):512-9 [PMID] 11505358.
View on: PubMed
2001
Comparison of bioimpedance versus thermodilution cardiac output during cardiac surgery: evaluation of a second-generation bioimpedance device.
Journal of cardiothoracic and vascular anesthesia. 15(5):567-73 [PMID] 11687996.
View on: PubMed
2001
Factor XIIIA and clot strength after cardiopulmonary bypass.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 12(2):101-8 [PMID] 11302471.
View on: PubMed
2001
Progress in the development of RBC substitutes.
Transfusion. 41(2):287-99 [PMID] 11239237.
View on: PubMed
2000
A second-generation blood substitute (Perfluorodichlorooctane emulsion) generates spurious elevations in platelet counts from automated hematology analyzers.
Anesthesia and analgesia. 90(3):517-22 [PMID] 10702429.
View on: PubMed
2000
Effect of propofol with and without EDTA on haemodynamics and calcium and magnesium homeostasis during and after cardiac surgery.
Intensive care medicine. 26 Suppl 4:S443-51 [PMID] 11310907.
View on: PubMed
2000
Institutional variability in red blood cell conservation practices for coronary artery bypass graft surgery. Institutions of the MultiCenter Study of Perioperative Ischemia Research Group.
Journal of cardiothoracic and vascular anesthesia. 14(2):171-6 [PMID] 10794337.
View on: PubMed
2000
Overview of myocardial outcome: the interrelationships among coagulation, inflammation, and endothelium.
Journal of cardiothoracic and vascular anesthesia. 14(3 Suppl 1):2-5; discussion 37 [PMID] 10890467.
View on: PubMed
2000
Unfractionated heparin for cardiopulmonary bypass: an unnatural act?
Journal of cardiothoracic and vascular anesthesia. 14(3):239-42 [PMID] 10890472.
View on: PubMed
1999
Maintenance of homeostasis in coagulation during cardiopulmonary bypass.
Journal of cardiothoracic and vascular anesthesia. 13(4 Suppl 1):2-5; discussion 36 [PMID] 10468242.
View on: PubMed
1999
Safety and efficacy of shed mediastinal blood transfusion after cardiac surgery: a multicenter observational study. Multicenter Study of Perioperative Ischemia Research Group.
Journal of cardiothoracic and vascular anesthesia. 13(4):410-6 [PMID] 10468253.
View on: PubMed
1998
A second-generation blood substitute (perfluorodichlorooctane emulsion) does not activate complement during an ex vivo circulation model of bypass.
Journal of cardiothoracic and vascular anesthesia. 12(4):397-401 [PMID] 9713726.
View on: PubMed
1998
Angiographic and histological evaluation of porcine retinal vascular damage and protection with perfluorocarbons after massive air embolism.
Stroke. 29(11):2396-403 [PMID] 9804654.
View on: PubMed
1998
Hematocrit value on intensive care unit entry influences the frequency of Q-wave myocardial infarction after coronary artery bypass grafting. The Institutions of the Multicenter Study of Perioperative Ischemia (McSPI) Research Group.
The Journal of thoracic and cardiovascular surgery. 116(3):460-7 [PMID] 9731788.
View on: PubMed
1998
Heparin-coated bypass circuits (Carmeda) suppress the release of tissue plasminogen activator during normothermic coronary artery bypass graft surgery.
Journal of cardiothoracic and vascular anesthesia. 12(3):299-304 [PMID] 9636912.
View on: PubMed
1998
Uses of antithrombin III concentrate in congenital and acquired deficiency states.
Transfusion. 38(5):481-98 [PMID] 9633563.
View on: PubMed
1998
Variability in transfusion practice for coronary artery bypass surgery persists despite national consensus guidelines: a 24-institution study. Institutions of the Multicenter Study of Perioperative Ischemia Research Group.
Anesthesiology. 88(2):327-33 [PMID] 9477051.
View on: PubMed
1997
A comparison of thromboelastography with heparinase or protamine sulfate added in vitro during heparinized cardiopulmonary bypass.
Thrombosis and haemostasis. 78(2):820-6 [PMID] 9268178.
View on: PubMed
1997
Excess mortality associated with the use of rapid infusion system at level 1 trauma center.
Resuscitation. 34(1):91-3 [PMID] 9051831.
View on: PubMed
1997
Horseradish peroxidase as a histological indicator of mechanisms of porcine retinal vascular damage and protection with perfluorocarbons after massive air embolism.
Stroke. 28(10):2025-30 [PMID] 9341714.
View on: PubMed
1997
Indicators of fibrinolysis during cardiopulmonary bypass after exogenous antithrombin-III administration for acquired antithrombin III deficiency.
Journal of cardiothoracic and vascular anesthesia. 11(6):760-3 [PMID] 9327320.
View on: PubMed
1997
Perfluorocarbon emulsion in the cardiopulmonary bypass prime reduces neurologic injury.
The Annals of thoracic surgery. 63(5):1326-32 [PMID] 9146323.
View on: PubMed
1997
Transesophageal echocardiography probe holder.
Anesthesia and analgesia. 85(4) [PMID] 9322487.
View on: PubMed
1996
Coagulation monitoring in the perioperative period.
Acta anaesthesiologica Scandinavica. Supplementum. 109:77-9 [PMID] 8901955.
View on: PubMed
1996
Endothelial cell injury in cardiovascular surgery: the procoagulant response.
The Annals of thoracic surgery. 62(5):1549-57 [PMID] 8893613.
View on: PubMed
1996
Hematologic changes in a patient with heparin-induced thrombocytopenia who underwent cardiopulmonary bypass after ancrod defibrinogenation.
Journal of cardiothoracic and vascular anesthesia. 10(7):918-21 [PMID] 8969402.
View on: PubMed
1996
Ischemia–a coagulation problem?
Journal of cardiovascular pharmacology. 27 Suppl 1:S38-41 [PMID] 8938282.
View on: PubMed
1996
Perfluorocarbon emulsions and cardiopulmonary bypass: a technique for the future.
Journal of cardiothoracic and vascular anesthesia. 10(1):83-89; quiz 89 [PMID] 8634391.
View on: PubMed
1996
The agreement between ventricular volumes and ejection fraction by transesophageal echocardiography or a combined radionuclear and thermodilution technique in patients after coronary artery surgery.
Journal of cardiothoracic and vascular anesthesia. 10(3):323-8 [PMID] 8725411.
View on: PubMed
1995
A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting.
Circulation. 92(8):2236-44 [PMID] 7554207.
View on: PubMed
1995
A perfluorocarbon emulsion prime additive improves the electroencephalogram and cerebral blood flow at the initiation of cardiopulmonary bypass.
The journal of extra-corporeal technology. 27(1):6-10 [PMID] 10150757.
View on: PubMed
1995
Changes in cardiovascular surgical approaches to achieve early extubation.
Journal of cardiothoracic and vascular anesthesia. 9(5 Suppl 1):10-5 [PMID] 8562895.
View on: PubMed
1995
Changes in transfusion therapy and reexploration rate after institution of a blood management program in cardiac surgical patients.
Journal of cardiothoracic and vascular anesthesia. 9(2):168-73 [PMID] 7780073.
View on: PubMed
1995
Perfluorocarbon emulsions: one approach to intravenous artificial respiratory gas transport.
International anesthesiology clinics. 33(1):103-13 [PMID] 7635552.
View on: PubMed
1995
Sudden cardiovascular collapse on skin closure after routine coronary artery bypass grafting.
Journal of cardiothoracic and vascular anesthesia. 9(5):609-11 [PMID] 8547570.
View on: PubMed
1995
Thromboelastography and cardiopulmonary bypass.
Seminars in thrombosis and hemostasis. 21 Suppl 4:27-33 [PMID] 8747685.
View on: PubMed
1994
Cardiac anesthesia risk management. Hemorrhage, coagulation, and transfusion: a risk-benefit analysis.
Journal of cardiothoracic and vascular anesthesia. 8(1 Suppl 1):19-22 [PMID] 8167299.
View on: PubMed
1994
Pro: autologous blood should be available for elective cardiac surgery.
Journal of cardiothoracic and vascular anesthesia. 8(2):231-7 [PMID] 8204816.
View on: PubMed
1994
Pulmonary artery and noninvasive hemodynamics during lung lavage in primary alveolar proteinosis.
Chest. 105(5):1605-8 [PMID] 8181374.
View on: PubMed
1993
Bioimpedance hemodynamics compared to pulmonary artery catheter monitoring during orthotopic liver transplantation.
The Journal of surgical research. 54(1):52-6 [PMID] 8429639.
View on: PubMed
1992
Autologous blood donation: hemodynamics in a high-risk patient population.
Transfusion. 32(1):17-22 [PMID] 1731430.
View on: PubMed
1992
Oxygen consumption and mixed venous oxygen saturation monitoring during orthotopic liver transplantation.
Journal of clinical monitoring. 8(1):7-11 [PMID] 1538256.
View on: PubMed
1992
Thromboelastogram and postoperative hemorrhage.
The Annals of thoracic surgery. 54(4):810-1; author reply 813 [PMID] 1417255.
View on: PubMed
1991
Complete airway obstruction of armored endotracheal tubes.
Anesthesia and analgesia. 73(1):95-6 [PMID] 1858998.
View on: PubMed
1991
The contribution of fibrinolysis to postbypass bleeding.
Journal of cardiothoracic and vascular anesthesia. 5(6 Suppl 1):13-7 [PMID] 1764571.
View on: PubMed
1990
Comparative effects of esmolol and verapamil in a model of a supraventricular tachydysrhythmia.
Anesthesiology. 73(3):467-73 [PMID] 1975485.
View on: PubMed
1990
Comparison of anesthetic techniques in patients undergoing heart valve replacement.
Journal of cardiothoracic anesthesia. 4(2):159-67 [PMID] 2151873.
View on: PubMed
1990
Sufentanil-midazolam anesthesia for coronary artery surgery.
Journal of cardiothoracic anesthesia. 4(3):308-13 [PMID] 1983403.
View on: PubMed
1989
Comparison of viscoelastic measures of coagulation after cardiopulmonary bypass.
Anesthesia and analgesia. 69(1):69-75 [PMID] 2742171.
View on: PubMed
1989
Does choice of anesthetic agent significantly affect outcome after coronary artery surgery?
Anesthesiology. 70(2):189-98 [PMID] 2563316.
View on: PubMed
1989
Effect of pulmonary artery catheterization on outcome in patients undergoing coronary artery surgery.
Anesthesiology. 70(2):199-206 [PMID] 2913857.
View on: PubMed
1989
The impact of liver transplant programs on anesthesia personnel and services.
Journal of clinical anesthesia. 1(3):186-93 [PMID] 2627386.
View on: PubMed
1988
Coagulation monitoring in the surgical intensive care unit.
Critical care clinics. 4(3):605-20 [PMID] 3063354.
View on: PubMed
1988
Effects of continuous arteriovenous hemofiltration on cardiopulmonary abnormalities during anesthesia for orthotopic liver transplantation.
Anesthesia and analgesia. 67(4):363-9 [PMID] 3281508.
View on: PubMed
1988
Effects of high-dose fentanyl on fluid and vasopressor requirements after cardiac surgery.
Journal of cardiothoracic anesthesia. 2(4):419-29 [PMID] 17171925.
View on: PubMed
1988
High frequency positive-pressure ventilation for anterior thoracic spine fusion after a previous pneumonectomy.
Anesthesia and analgesia. 67(4):411-4 [PMID] 3354878.
View on: PubMed
1988
Sufentanil-midazolam anesthesia in malignant hyperthermia.
Anesthesia and analgesia. 67(4):405-8 [PMID] 2895595.
View on: PubMed
1988
The incidence of venous air embolism during total hip arthroplasty.
Journal of clinical anesthesia. 1(1):25-30 [PMID] 3078522.
View on: PubMed
1988
Thromboelastography used for detection of perioperative fibrinolysis: a report of four cases.
Journal of cardiothoracic anesthesia. 2(5):666-72 [PMID] 17171959.
View on: PubMed
1988
Treatment of decompression sickness with a perfluorocarbon emulsion (FC-43).
Undersea biomedical research. 15(1):31-7 [PMID] 3368993.
View on: PubMed
1987
Effects of nitrous oxide on coronary perfusion after coronary air embolism.
Anesthesiology. 67(6):952-9 [PMID] 3688538.
View on: PubMed
1987
Effects of progressive blood loss on coagulation as measured by thrombelastography.
Anesthesia and analgesia. 66(9):856-63 [PMID] 3619091.
View on: PubMed
1987
Perfluorocarbon emulsions and air embolism.
The Annals of thoracic surgery. 44(2) [PMID] 3619548.
View on: PubMed
1987
Protection from coronary air embolism by a perfluorocarbon emulsion (FC-43).
Journal of cardiothoracic anesthesia. 1(3):210-5 [PMID] 2979096.
View on: PubMed
1987
Thromboelastography as an indicator of post-cardiopulmonary bypass coagulopathies.
Journal of clinical monitoring. 3(1):25-30 [PMID] 3819793.
View on: PubMed
1987
Use of thromboelastography in the management of von Willebrand’s disease during cardiopulmonary bypass.
Journal of cardiothoracic anesthesia. 1(4):321-4 [PMID] 17165316.
View on: PubMed
1986
Cardiorespiratory effects of venous air embolism in dogs receiving a perfluorocarbon emulsion.
Journal of neurosurgery. 65(2):238-44 [PMID] 2425063.
View on: PubMed
1986
High-dose sufentanil: four cases of sudden hypotension on induction.
Anesthesia and analgesia. 65(6):703-5 [PMID] 2939780.
View on: PubMed
1986
Protection from cerebral air emboli with perfluorocarbons in rabbits.
Stroke. 17(6):1146-9 [PMID] 2433815.
View on: PubMed
1986
Protection from venous air embolism with fluorocarbon emulsion FC-43.
The Journal of surgical research. 41(4):439-44 [PMID] 3773504.
View on: PubMed
1984
Requirements for paediatric blood pressure cuffs.
Helvetica paediatrica acta. 39(2):117-22 [PMID] 6543834.
View on: PubMed

Grants

Mar 2021 ACTIVE
Local Oxygen Delivery with Silk Fibbroin-Based Microparticles Loaded with Salmon Hemoglobin
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Mar 2021 ACTIVE
Preservation of spinal cord tissue resulting from Ischemia following Aortic Surgery: creation of a clinically relevant rodent model and testing of a novel oxygen release therapeutic
Role: Principal Investigator
Funding: UF FOU
Mar 2021 ACTIVE
Preservation of spinal cord tissue resulting from Ischemia following Aortic Surgery: creation of a clinically relevant rodent model and testing of a novel oxygen release therapeutic
Role: Principal Investigator
Funding: UF FOU
Jan 2021 ACTIVE
Dodecafluoropentane to Reduce Ischemic-Reperfusion Injury in a Swine Model of Cardiac Arrest
Role: Other
Funding: ZOLL FOUNDATION
Sep 2020 – Apr 2021
HemoClear Millipore Filtration of Chest Tube Drainage in Cardiac Surgery: A Benchtop Proof of Concept to Cleanse Captured Postoperative Drainage
Role: Principal Investigator
Funding: Hemoclear
Oct 2017 – Sep 2018
Hemoclear Millipore Filtration of Chest Tube Drainage in Cardiac Surgery: A Benchtop Proof of Concept to Cleanse Captured Postoperative Drainage
Role: Principal Investigator
Funding: Hemoclear via NETHERLANDS HEART FOUNDATION
Jul 2014 – Jul 2017
A Prospective, Multicenter, Randomized, Double Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Preoperative Antithrombin Supplement in Patients Undergoing High Risk Cardiac Surgery with Cardiopulmonary Bypass
Role: Principal Investigator
Funding: CLINIPACE INC via GRIFOLS SA

Education

Residency, Anesthesiology
1983 · Mayo Clinic Graduate School of Medicine
MD
1980 · Rush University Medical College

Contact Details

Phones:
Business:
(352) 273-8952
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