Christoph N Seubert, MD, PhD, DABNM
Professor Of Anesthesiology And Neurosurgery
Department:
MD-ANESTHESIOLOGY-GENERAL
Business Phone:
(352) 273-8960
Business Email:
cseubert@anest.ufl.edu
About Christoph N Seubert
Dr. Seubert is a Professor of Anesthesiology and Neurosurgery and the Chief of the Division of Neuroanesthesia at the University of Florida. He received his medical degree from Julius-Maximilians-Universität in Würzburg, Germany, and his Ph.D. from Albert-Ludwigs-Universität in Freiburg, Germany.
Dr. Seubert completed his residency in anesthesiology at the University of Heidelberg in Heidelberg, Germany. Additionally, he completed an anesthesiology residency, as well as a fellowship in cardiothoracic and vascular anesthesia, here at the University of Florida. His clinical interests are in anesthesia for neurosurgical procedures and intraoperative neurophysiologic monitoring.
Teaching Profile
Courses Taught
2018
PHA7980 Research for Doctoral Dissertation
Board Certifications
-
AnesthesiologyAmerican Board of Anesthesiology
-
Pediatric AnesthesiologyAmerican Board of Anethesiology
Clinical Profile
Specialties
- Anesthesiology
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-4502-4201
Publications
2024
Neurobehavioral Abnormalities in Offspring of Young Adult Male Rats With a History of Traumatic Brain Injury.
Journal of neurotrauma.
41(7-8):969-984
[DOI] 10.1089/neu.2023.0364.
[PMID] 38279844.
2023
Analyzing the value of IONM as a complex intervention: The gap between published evidence and clinical practice
Clinical Neurophysiology.
151:59-73
[DOI] 10.1016/j.clinph.2023.03.364.
2023
Cohabitation of Neonatally Sevoflurane-exposed and -unexposed Male Rats Affects Their Respective Behavioral Phenotypes: Research Letter.
Anesthesiology.
138(6):658-661
[DOI] 10.1097/ALN.0000000000004546.
[PMID] 37017655.
2023
Frailty Assessment and Prehabilitation Before Complex Spine Surgery in Patients With Degenerative Spine Disease: A Narrative Review.
Journal of neurosurgical anesthesiology.
35(1):19-30
[DOI] 10.1097/ANA.0000000000000787.
[PMID] 34354024.
2023
Intergenerational Perioperative Neurocognitive Disorder
Biology.
12(4)
[DOI] 10.3390/biology12040567.
[PMID] 37106766.
2023
Intergenerational Perioperative Neurocognitive Disorder in Young Adult Male Rats with Traumatic Brain Injury.
Anesthesiology.
138(4):388-402
[DOI] 10.1097/ALN.0000000000004496.
[PMID] 36637480.
2023
The Enhanced Recovery After Surgery pathway for posterior cervical surgery: a retrospective propensity-matched cohort study.
Journal of neurosurgery. Spine.
39(2):216-227
[DOI] 10.3171/2023.2.SPINE221174.
[PMID] 37119104.
2022
Enhanced recovery after surgery (ERAS) for open transforaminal lumbar interbody fusion: a retrospective propensity-matched cohort study
The Spine Journal.
22(3):399-410
[DOI] 10.1016/j.spinee.2021.10.007.
[PMID] 34687905.
2022
Enhanced recovery after surgery (ERAS) improves return of physiological function in frail patients undergoing one- to two-level TLIFs: an observational retrospective cohort study
The Spine Journal.
22(9):1513-1522
[DOI] 10.1016/j.spinee.2022.04.007.
[PMID] 35447326.
2022
Utility of evoked potentials during anterior cerebral artery and anterior communicating artery aneurysm clipping.
Clinical neurophysiology practice.
7:228-238
[DOI] 10.1016/j.cnp.2022.07.001.
[PMID] 35935596.
2021
Best Practices in Facial Nerve Monitoring
The Laryngoscope.
131(S4)
[DOI] 10.1002/lary.29459.
2021
Letter to the Editor. What are the odds: worse outcomes with IONM?
Journal of neurosurgery.
136(1):321-322
[DOI] 10.3171/2021.4.JNS21918.
[PMID] 34479195.
2020
Methadone and a Clinical Pathway in Adolescent Idiopathic Scoliosis Surgery: A Historically Controlled Study
Global Spine Journal.
10(7):837-843
[DOI] 10.1177/2192568219878135.
[PMID] 32905725.
2020
Neuroanesthesiologists as interoperative neurophysiologists: a collaborative cognitive apprenticeship model of training in a community of clinical practice.
Journal of clinical monitoring and computing.
34(2):325-330
[DOI] 10.1007/s10877-019-00304-0.
[PMID] 30955161.
2020
Transcranial Motor Evoked Potential Monitoring in a Patient With a Deep Brain Stimulator: A Case Report
Journal of Clinical Neurophysiology.
38(1):e1-e4
[DOI] 10.1097/WNP.0000000000000705.
[PMID] 32501949.
2019
Acceptance of a propofol and remifentanil infusion dosing algorithm to optimize postoperative emergence and analgesia.
Journal of clinical monitoring and computing.
33(6):953-957
[DOI] 10.1007/s10877-019-00295-y.
[PMID] 30868345.
2019
Correction to: Is the new ASNM intraoperative neuromonitoring supervision “guideline” a trustworthy guideline? A commentary.
Journal of clinical monitoring and computing.
33(2):191-192
[DOI] 10.1007/s10877-019-00266-3.
[PMID] 30778916.
2019
Intergenerational Effects of Sevoflurane in Young Adult Rats.
Anesthesiology.
131(5):1092-1109
[DOI] 10.1097/ALN.0000000000002920.
[PMID] 31517640.
2019
Is the new ASNM intraoperative neuromonitoring supervision “guideline” a trustworthy guideline? A commentary.
Journal of clinical monitoring and computing.
33(2):185-190
[DOI] 10.1007/s10877-018-00242-3.
[PMID] 30612285.
2019
Proof of principle: Preoperative cognitive reserve and brain integrity predicts intra-individual variability in processed EEG (Bispectral Index Monitor) during general anesthesia.
PloS one.
14(5)
[DOI] 10.1371/journal.pone.0216209.
[PMID] 31120896.
2018
Effects of combined brief etomidate anesthesia and postnatal stress on amygdala expression of Cl- cotransporters and corticotropin-releasing hormone and alcohol intake in adult rats.
Neuroscience letters.
685:83-89
[DOI] 10.1016/j.neulet.2018.08.019.
[PMID] 30125644.
2018
Not Everything That Shakes Is a Seizure: A Case Report
A&A practice.
10(10):267-271
[DOI] 10.1213/XAA.0000000000000682.
[PMID] 29293485.
2018
Role of epigenetic mechanisms in transmitting the effects of neonatal sevoflurane exposure to the next generation of male, but not female, rats.
British journal of anaesthesia.
121(2):406-416
[DOI] 10.1016/j.bja.2018.04.034.
[PMID] 30032879.
2018
Simultaneous Retrodialysis by Calibrator for Rapid In Vivo Recovery Determination in Target Site Microdialysis.
Journal of pharmaceutical sciences.
107(8):2259-2265
[DOI] 10.1016/j.xphs.2018.04.021.
[PMID] 29715477.
2017
Drugs in space: Pharmacokinetics and pharmacodynamics in astronauts.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
109S:S2-S8
[DOI] 10.1016/j.ejps.2017.05.025.
[PMID] 28533143.
2017
Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.
Psychoneuroendocrinology.
81:96-104
[DOI] 10.1016/j.psyneuen.2017.04.001.
[PMID] 28433802.
2016
A Prospective Time-Series Quality Improvement Trial of a Standardized Analgesia Protocol to Reduce Postoperative Pain Among Neurosurgery Patients
Journal of Neurosurgery.
125(6):1523-1532
[DOI] 10.3171/2015.10.JNS15698.
2016
Neurophysiological monitoring and spinal cord integrity.
Best practice & research. Clinical anaesthesiology.
30(1):53-68
[DOI] 10.1016/j.bpa.2015.11.006.
[PMID] 27036603.
2016
Propofol, but not etomidate, increases corticosterone levels and induces long-term alteration in hippocampal synaptic activity in neonatal rats.
Neuroscience letters.
618:1-5
[DOI] 10.1016/j.neulet.2016.02.045.
[PMID] 26923669.
2016
Role of Steroids in Hyperexcitatory Adverse and Anesthetic Effects of Sevoflurane in Neonatal Rats.
Neuroendocrinology.
103(5):440-51
[DOI] 10.1159/000437267.
[PMID] 26159049.
2015
Anesthesia with sevoflurane in neonatal rats: Developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl(-) importer antagonists.
Psychoneuroendocrinology.
60:173-81
[DOI] 10.1016/j.psyneuen.2015.06.016.
[PMID] 26150359.
2015
Propofol-induced electroencephalographic seizures in neonatal rats: the role of corticosteroids and Îł-aminobutyric acid type A receptor-mediated excitation.
Anesthesia and analgesia.
120(2):433-9
[DOI] 10.1213/ANE.0000000000000529.
[PMID] 25390279.
2015
Prospective Pilot Investigation: Presurgical Depressive Symptom Severity and Anesthesia Response in Women Undergoing Surgery for Gynecologic Mass Removal.
International journal of behavioral medicine.
22(4):521-9
[DOI] 10.1007/s12529-014-9451-1.
[PMID] 25421878.
2014
Endocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats.
Anesthesiology.
121(5):1010-7
[DOI] 10.1097/ALN.0000000000000366.
[PMID] 24992523.
2013
Clinical Implications of Bilirubin-Associated Neuroprotection and Neurotoxicity.
International journal of clinical anesthesiology.
1(2)
[PMID] 29911128.
2013
Developmental effects of neonatal isoflurane and sevoflurane exposure in rats.
Anesthesiology.
119(2):358-64
[DOI] 10.1097/ALN.0b013e318291c04e.
[PMID] 23619170.
2013
Developmental Effects of Sevoflurane in Rats May Involve the Anesthetic-Caused Dysregulation of the Hypothalamic-Pituitary-Adrenal (Hpa) Axis
Anesthesia and Analgesia.
116(1)
2013
Electroencephalogram effects of armodafinil: comparison with behavioral alertness.
Journal of clinical pharmacology.
53(10):1058-71
[DOI] 10.1002/jcph.143.
[PMID] 23913585.
2012
Pharmacokinetic-Pharmacodynamic Modeling of Armodafinil: Effects On Alertness and Electroen-Cephalogram of Sleep Deprived Adults
Clinical Pharmacology & Therapeutics.
91:S7-S8
2012
Roles of aldosterone and oxytocin in abnormalities caused by sevoflurane anesthesia in neonatal rats.
Anesthesiology.
117(4):791-800
[PMID] 22854980.
2012
Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.
International journal of antimicrobial agents.
40(1):51-4
[DOI] 10.1016/j.ijantimicag.2012.03.006.
[PMID] 22584101.
2011
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
Amino acids.
40(4):1151-8
[DOI] 10.1007/s00726-010-0739-4.
[PMID] 20839013.
2011
Population Pharmacokinetics and Pharmacodynamics of Armodafinil: Effects On Electroencephalogram and Alertness of Sleep Deprived Adults
.
51
2011
Transient bilateral brainstem dysfunction caused by topical administration of papaverine.
Journal of neurosurgery.
[PMID] 21721877.
2010
Bumetanide alleviates epileptogenic and neurotoxic effects of sevoflurane in neonatal rat brain.
Anesthesiology.
112(3):567-75
[DOI] 10.1097/ALN.0b013e3181cf9138.
[PMID] 20124973.
2009
3,5-Dibromo-L-Phenylalanine Depresses Pentylenetetrazole-Induced Seizures and Reduces Neurological and Sensorimotor Gating Deficits Caused By Stroke
Journal of the Neurological Sciences.
285
2009
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
British journal of pharmacology.
158(8):2005-13
[PMID] 20050189.
2009
Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.
Antimicrobial agents and chemotherapy.
53(7):2773-6
[DOI] 10.1128/AAC.01409-08.
[PMID] 19364847.
2008
Anesthesia in Space – Pk/Pd Modeling of Propofol in Simulated Microgravity
.
48
2006
Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders.
Recent patents on CNS drug discovery.
1(3):261-70
[PMID] 18221208.
2005
Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine.
Molecular pharmacology.
67(5):1648-54
[PMID] 15687225.
2005
Impaired glutamatergic synaptic transmission in the PKU brain.
Molecular genetics and metabolism.
86 Suppl 1:S34-42
[PMID] 16153867.
2005
Long-term changes in glutamatergic synaptic transmission in phenylketonuria.
Brain : a journal of neurology.
128(Pt 2):300-7
[PMID] 15634735.
2005
Mass spectral fragmentation of the intravenous anesthetic propofol and structurally related phenols.
Journal of the American Society for Mass Spectrometry.
16(6):814-24
[PMID] 15907697.
2004
A new method for the quantitation of propofol in human plasma: efficient solid-phase extraction and liquid chromatography/APCI-triple quadrupole mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
810(2):291-6
[PMID] 15380727.
2004
Bispectral index decline caused by neuromuscular blockade.
Anesthesia and analgesia.
98(3):871; author reply 873-4
[PMID] 14980957.
2004
Neuroprotective action of halogenated derivatives of L-phenylalanine.
Stroke.
35(5):1192-6
[PMID] 15073406.
2004
Pluronic microemulsions as nanoreservoirs for extraction of bupivacaine from normal saline.
Journal of the American Chemical Society.
126(16):5108-12
[PMID] 15099093.
2004
The effect of body inclination during prone positioning on intraocular pressure in awake volunteers: a comparison of two operating tables.
Anesthesia and analgesia.
99(4):1152-1158
[DOI] 10.1213/01.ANE.0000130851.37039.50.
[PMID] 15385367.
2003
L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses.
Journal of neuroscience research.
72(1):116-24
[PMID] 12645085.
2003
Transient paraplegia after stent grafting of a descending thoracic aortic aneurysm treated with cerebrospinal fluid drainage.
Journal of clinical anesthesia.
15(1):59-63
[PMID] 12657411.
2002
Contribution of I(K,ADO) to the negative dromotropic effect of adenosine.
Basic research in cardiology.
97(4):286-94
[PMID] 12111038.
2002
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism.
Basic research in cardiology.
97(4):295-304
[PMID] 12111039.
2002
Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria.
Molecular psychiatry.
7(4):359-67
[PMID] 11986979.
2001
Structure-activity relationships and electrophysiological effects of short-acting amiodarone homologs in guinea pig isolated heart.
The Journal of pharmacology and experimental therapeutics.
297(1):260-6
[PMID] 11259553.
2000
Antagonism of the positive dromotropic effect of isoproterenol by adenosine: role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G.
Journal of molecular and cellular cardiology.
32(9):1609-19
[PMID] 10966824.
2000
Midazolam selectively potentiates the A(2A) – but not A1- receptor–mediated effects of adenosine: role of nucleoside transport inhibition and clinical implications.
Anesthesiology.
92(2):567-77
[PMID] 10691246.
2000
Role of A(2A)-adenosine receptor activation for ATP-mediated coronary vasodilation in guinea-pig isolated heart.
British journal of pharmacology.
130(5):1065-75
[PMID] 10882391.
1999
Cardiac arrest after uncomplicated right upper lobectomy.
Journal of cardiothoracic and vascular anesthesia.
13(1):105-6
[PMID] 10069295.
1999
Ionic mechanisms mediating the differential effects of methohexital and thiopental on action potential duration in guinea pig and rabbit isolated ventricular myocytes.
Anesthesiology.
90(1):156-64
[PMID] 9915324.
1999
Presence of an echogenic mass on the pulmonary valve and right ventricular outflow tract.
Journal of cardiothoracic and vascular anesthesia.
13(6):789-90
[PMID] 10622667.
Grants
Nov 2021
ACTIVE
Preoperative sleep spindles and delirium in Alzheimer's Disease
Role: Other
Funding: ALZHEIMERS ASSO
Education
Fellowship – Cardiovascular Anesthesia
2000
·
University of Florida
Residency – Anesthesiology
1998
·
University of Florida
Residency – Internal Medicine
1995
·
Memorial Medical Center
Medical Degree
1991
·
Albert-Ludwigs Universitat
PhD
1991
·
Julius-Maximilians University
Contact Details
Phones:
- Business:
- (352) 273-8960
Emails:
- Business:
- cseubert@anest.ufl.edu
Addresses:
- Business Mailing:
-
1345 SW Center Drive
GAINESVILLE FL 32610 - Business Street:
-
1345 SW Center Drive, PO Box 100254
GAINESVILLE FL 32610