Anatoly E Martynyuk

Anatoly E Martynyuk, PhD

Professor Of Anesthesiology And Neuroscience

Department: MD-ANESTHESIOLOGY-GENERAL
Business Phone: (352) 294-8344
Business Email: amartynyuk@anest.ufl.edu

About Anatoly E Martynyuk

Dr. Anatoly Martynyuk is a Professor of Anesthesiology and Neuroscience in the divisions of Research and Neuroanesthesia and a member of the McKnight Brain Institute. Dr. Martynyuk earned a Master of Science degree from Kiev State University as well as his PhD and DSc in biophysics from Bogomoletz Institute of Physiology in Kiev, Ukraine. Following this, he completed a postdoctoral training at University of Glasgow, Glasgow, UK.

Dr. Martynyuk is a biophysicist and neuroscientist investigating mechanisms of developmental neurobehavioral effects of exposure to general anesthetic agents. His research interests also extend to mechanisms of brain dysfunction in phenylketonuria, as well as to new therapeutic approaches to treat stroke and supraventricular tachycardia. He has published his research in various journals, including Molecular Psychiatry, Brain, Circulation, Stroke, Anesthesiology, and the British Journal of Anaestesia.

Dr. Martynyuk has been a principal investigator on projects funded by the National Institute of General Medicine and National Institute of Neurological Disorders and Stroke. Dr. Martynyuk has extensive collaborative links within the University of Florida and internationally. He currently serves as a foreign collaborator on three research grants funded by the National Natural Science Foundation of China. Dr. Martynyuk is on editorial boards of several scientific journals and serves as a reviewer of research grants for NIH and many foreign agencies.

Publications

2021
The potential role of stress and sex steroids in heritable effects of sevoflurane†.
Biology of reproduction. 105(3):735-746 [DOI] 10.1093/biolre/ioab129. [PMID] 34192761.
2020
A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane.
Anesthesia and analgesia. 131(4):1291-1299 [DOI] 10.1213/ANE.0000000000005097. [PMID] 32925350.
2020
Neonatal exposure to sevoflurane expands the window of vulnerability to adverse effects of subsequent exposure to sevoflurane and alters hippocampal morphology via decitabine-sensitive mechanisms.
Neuroscience letters. 735 [DOI] 10.1016/j.neulet.2020.135240. [PMID] 32650051.
2020
Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics.
World journal of psychiatry. 10(5):81-94 [DOI] 10.5498/wjp.v10.i5.81. [PMID] 32477904.
2020
Roles of Testosterone and Estradiol in Mediation of Acute Neuroendocrine and Electroencephalographic Effects of Sevoflurane During the Sensitive Period in Rats.
Frontiers in endocrinology. 11 [DOI] 10.3389/fendo.2020.545973. [PMID] 33101193.
2020
The Estradiol Synthesis Inhibitor Formestane Diminishes the Ability of Sevoflurane to Induce Neurodevelopmental Abnormalities in Male Rats.
Frontiers in systems neuroscience. 14 [DOI] 10.3389/fnsys.2020.546531. [PMID] 33013333.
2019
Intergenerational Effects of Sevoflurane in Young Adult Rats.
Anesthesiology. 131(5):1092-1109 [DOI] 10.1097/ALN.0000000000002920. [PMID] 31517640.
2018
Effects of combined brief etomidate anesthesia and postnatal stress on amygdala expression of Cl- cotransporters and corticotropin-releasing hormone and alcohol intake in adult rats.
Neuroscience letters. 685:83-89 [DOI] 10.1016/j.neulet.2018.08.019. [PMID] 30125644.
2018
Role of epigenetic mechanisms in transmitting the effects of neonatal sevoflurane exposure to the next generation of male, but not female, rats.
British journal of anaesthesia. 121(2):406-416 [DOI] 10.1016/j.bja.2018.04.034. [PMID] 30032879.
2017
Neurodevelopmental effects of anesthesia and environmental factors.
Oncotarget. 8(6):9009-9010 [DOI] 10.18632/oncotarget.14694. [PMID] 28107183.
2017
Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.
Psychoneuroendocrinology. 81:96-104 [DOI] 10.1016/j.psyneuen.2017.04.001. [PMID] 28433802.
2017
Subsequent maternal separation exacerbates neurobehavioral abnormalities in rats neonatally exposed to sevoflurane anesthesia.
Neuroscience letters. 661:137-142 [DOI] 10.1016/j.neulet.2017.09.063. [PMID] 28982596.
2017
The Combination of Long-term Ketamine and Extinction Training Contributes to Fear Erasure by Bdnf Methylation.
Frontiers in cellular neuroscience. 11 [DOI] 10.3389/fncel.2017.00100. [PMID] 28473755.
2016
Propofol, but not etomidate, increases corticosterone levels and induces long-term alteration in hippocampal synaptic activity in neonatal rats.
Neuroscience letters. 618:1-5 [DOI] 10.1016/j.neulet.2016.02.045. [PMID] 26923669.
2016
Role of histone acetylation in long-term neurobehavioral effects of neonatal Exposure to sevoflurane in rats.
Neurobiology of disease. 91:209-220 [DOI] 10.1016/j.nbd.2016.03.017. [PMID] 27001149.
2016
Role of Steroids in Hyperexcitatory Adverse and Anesthetic Effects of Sevoflurane in Neonatal Rats.
Neuroendocrinology. 103(5):440-51 [DOI] 10.1159/000437267. [PMID] 26159049.
2015
Anesthesia with sevoflurane in neonatal rats: Developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl(-) importer antagonists.
Psychoneuroendocrinology. 60:173-81 [DOI] 10.1016/j.psyneuen.2015.06.016. [PMID] 26150359.
2015
Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic.
British journal of anaesthesia. 115(5):752-60 [DOI] 10.1093/bja/aev339. [PMID] 26475803.
2015
Propofol-induced electroencephalographic seizures in neonatal rats: the role of corticosteroids and γ-aminobutyric acid type A receptor-mediated excitation.
Anesthesia and analgesia. 120(2):433-9 [DOI] 10.1213/ANE.0000000000000529. [PMID] 25390279.
2014
Endocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats.
Anesthesiology. 121(5):1010-7 [DOI] 10.1097/ALN.0000000000000366. [PMID] 24992523.
2013
Developmental effects of neonatal isoflurane and sevoflurane exposure in rats.
Anesthesiology. 119(2):358-64 [DOI] 10.1097/ALN.0b013e318291c04e. [PMID] 23619170.
2013
Developmental Effects of Sevoflurane in Rats May Involve the Anesthetic-Caused Dysregulation of the Hypothalamic-Pituitary-Adrenal (Hpa) Axis
Anesthesia and Analgesia. 116(1)
2012
Roles of aldosterone and oxytocin in abnormalities caused by sevoflurane anesthesia in neonatal rats.
Anesthesiology. 117(4):791-800 [PMID] 22854980.
View on: PubMed
2011
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
Amino acids. 40(4):1151-8 [DOI] 10.1007/s00726-010-0739-4. [PMID] 20839013.
2010
Animal models of brain dysfunction in phenylketonuria.
Molecular genetics and metabolism. 99 Suppl 1:S100-5 [DOI] 10.1016/j.ymgme.2009.10.181. [PMID] 20123463.
2010
Bumetanide alleviates epileptogenic and neurotoxic effects of sevoflurane in neonatal rat brain.
Anesthesiology. 112(3):567-75 [DOI] 10.1097/ALN.0b013e3181cf9138. [PMID] 20124973.
2009
3,5-Dibromo-L-Phenylalanine Depresses Pentylenetetrazole-Induced Seizures and Reduces Neurological and Sensorimotor Gating Deficits Caused By Stroke
Journal of the Neurological Sciences. 285
2009
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
British journal of pharmacology. 158(8):2005-13 [PMID] 20050189.
View on: PubMed
2007
Basal and angiotensin II-inhibited neuronal delayed-rectifier K+ current are regulated by thioredoxin.
American journal of physiology. Cell physiology. 293(1):C211-7 [PMID] 17360810.
View on: PubMed
2007
Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels.
Epilepsia. 48(6):1143-50 [PMID] 17484755.
View on: PubMed
2007
PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice.
Brain research. 1127(1):136-50 [PMID] 17112485.
View on: PubMed
2006
Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders.
Recent patents on CNS drug discovery. 1(3):261-70 [PMID] 18221208.
View on: PubMed
2006
Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current.
Journal of neurophysiology. 95(2):1042-8 [PMID] 16267117.
View on: PubMed
2005
Adenoviral-mediated neuron specific transduction of angiotensin II type 2 receptors.
Regulatory peptides. 126(3):213-22 [PMID] 15664669.
View on: PubMed
2005
Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine.
Molecular pharmacology. 67(5):1648-54 [PMID] 15687225.
View on: PubMed
2005
Impaired glutamatergic synaptic transmission in the PKU brain.
Molecular genetics and metabolism. 86 Suppl 1:S34-42 [PMID] 16153867.
View on: PubMed
2005
Long-term changes in glutamatergic synaptic transmission in phenylketonuria.
Brain : a journal of neurology. 128(Pt 2):300-7 [PMID] 15634735.
View on: PubMed
2004
Neuroprotective action of halogenated derivatives of L-phenylalanine.
Stroke. 35(5):1192-6 [PMID] 15073406.
View on: PubMed
2003
Free radicals potentiate the negative dromotropic effect of adenosine in guinea pig isolated heart.
Acta cardiologica. 58(3):191-7 [PMID] 12846508.
View on: PubMed
2003
L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses.
Journal of neuroscience research. 72(1):116-24 [PMID] 12645085.
View on: PubMed
2002
Contribution of I(K,ADO) to the negative dromotropic effect of adenosine.
Basic research in cardiology. 97(4):286-94 [PMID] 12111038.
View on: PubMed
2002
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism.
Basic research in cardiology. 97(4):295-304 [PMID] 12111039.
View on: PubMed
2002
Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria.
Molecular psychiatry. 7(4):359-67 [PMID] 11986979.
View on: PubMed
2001
Structure-activity relationships and electrophysiological effects of short-acting amiodarone homologs in guinea pig isolated heart.
The Journal of pharmacology and experimental therapeutics. 297(1):260-6 [PMID] 11259553.
View on: PubMed
2000
Antagonism of the positive dromotropic effect of isoproterenol by adenosine: role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G.
Journal of molecular and cellular cardiology. 32(9):1609-19 [PMID] 10966824.
View on: PubMed
2000
Midazolam selectively potentiates the A(2A) – but not A1- receptor–mediated effects of adenosine: role of nucleoside transport inhibition and clinical implications.
Anesthesiology. 92(2):567-77 [PMID] 10691246.
View on: PubMed
1999
Hyperkalemia enhances the effect of adenosine on IK,ADO in rabbit isolated AV nodal myocytes and on AV nodal conduction in guinea pig isolated heart.
Circulation. 99(2):312-8 [PMID] 9892600.
View on: PubMed
1999
Ionic mechanisms mediating the differential effects of methohexital and thiopental on action potential duration in guinea pig and rabbit isolated ventricular myocytes.
Anesthesiology. 90(1):156-64 [PMID] 9915324.
View on: PubMed
1997
Ionic basis of the differential effects of intravenous anesthetics on erythromycin-induced prolongation of ventricular repolarization in the guinea pig heart.
Anesthesiology. 87(5):1172-81 [PMID] 9366470.
View on: PubMed
1997
Ionic mechanisms of the effect of adenosine on single rabbit atrioventricular node myocytes.
The Canadian journal of cardiology. 13(12):1183-7 [PMID] 9444300.
View on: PubMed
1997
Role of nitric oxide, cyclic GMP and superoxide in inhibition by adenosine of calcium current in rabbit atrioventricular nodal cells.
Cardiovascular research. 34(2):360-7 [PMID] 9205550.
View on: PubMed
1996
Nitric oxide mediates the anti-adrenergic effect of adenosine on calcium current in isolated rabbit atrioventricular nodal cells.
Pflugers Archiv : European journal of physiology. 431(3):452-7 [PMID] 8584441.
View on: PubMed
1995
Adenosine increases potassium conductance in isolated rabbit atrioventricular nodal myocytes.
Cardiovascular research. 30(5):668-75 [PMID] 8595611.
View on: PubMed
1991
Blocking effect of intraperitoneal injection of phenylalanine on high-threshold calcium currents in rat hippocampal neurones.
Brain research. 552(2):228-31 [PMID] 1655169.
View on: PubMed
1991
Effects of intracellular administration of L-tyrosine and L-phenylalanine on voltage-operated calcium conductance in PC12 pheochromocytoma cells.
Brain research. 550(1):11-4 [PMID] 1653634.
View on: PubMed
1985
Fast decrease of the peak current carried by barium ions through calcium channels in the somatic membrane of mollusc neurons.
Pflugers Archiv : European journal of physiology. 404(1):88-90 [PMID] 2409522.
View on: PubMed
1984
Inactivation of calcium current in the somatic membrane of snail neurons.
General physiology and biophysics. 3(1):1-17 [PMID] 6086448.
View on: PubMed

Grants

Sep 2020 ACTIVE
Mechanisms of neurodevelopmental effects of parental exposure to commonly used general anesthetic agents
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Jun 2018 – May 2021
OR-DRPD-ROF2018: A commonly used human anesthetic may act as an endocrine disruptor, contributing to sex-dependent developmental effects of neonatal anesthesia
Role: Co-Investigator
Funding: UF RESEARCH
Dec 2017 – Nov 2019
Multigenerational neurobehavioral effects of sevoflurane
Role: Principal Investigator
Funding: HEERMANN ANESTHESIA FOU, I
Dec 2016 – Dec 2020
MISCELLANEOUS DONORS
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Sep 2015 – Aug 2020
Role of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis and gamma-aminobutyric acid type A receptor (GABAAR)-mediated excitation in the developmental central and systemic effects of neonatal anesthesia.
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2011 – Mar 2016
Mechanism of Neurological and Cognitive Side Effects of Sevoflurane Anesthesia at Early Stages of Brain Development.
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS

Patents

Published January 2007
Methods and Materials for Treating Mental Illness
#US-2008-0096870-A1
Published November 2006
Materials and Methods for Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors
#2007/70088074
Published June 2004
Materials and Methods for Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors
#US-2004-0266851-A1
Issued September 2003
Materials and Methods for Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors.
#6,620,850
Published July 2003
Materials and Methods For Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors
#US-2004-0147590-A1
Published April 2003
Materials and Methods for Treatment of Neurological Disorders Involving Overactivation of Glutamatergic Ionotropic Receptors
#US-2003-0216472

Education

Postdoctoral Fellowship, Research
1995 · University of Glasgow
DSc, Biological Sciences in Biophysics
1992 · Bogomoletz Institute of Physiology
PhD, Biophysics
1982 · Bogomoletz Institute of Physiology
MSc, Biology and Biophysics
1979 · Kiev State University

Teaching Profile

Courses Taught
2014-2018
GMS6023 Principles of Neuroscience III: Molecular Neuropharmacology and its Clinical Application
2013,2015-2017,2017
GMS6051 Signal Transduction
2014
GMS6029 Brain Journal Club
2013
GMS7794 Neuroscience Seminar

Contact Details

Phones:
Business:
(352) 294-8344
Emails: