Sylvain Doré

Sylvain Doré PhD, FAHA

Professor of Anesthesiology, Neurology, Psychiatry, and Neuroscience

Department: MD-ANESTHESIOLOGY-GENERAL
Business Phone: (352) 273-9663
Business Email: sdore@ufl.edu

About Sylvain Doré

Sylvain Doré, PhD, is a Professor of Anesthesiology in the Division of Research, as well as a Professor of Neurology, Psychiatry, Pharmaceutics, and Neuroscience, at the University of Florida, College of Medicine.

Dr. Doré attained his PhD in biomedical science from the University of Montreal and an MS degree in pharmacology at the University of Quebec. He received post-PhD training in psychiatry at McGill University, as well as post-PhD training in neuroscience at Johns Hopkins University.

Dr. Doré’s research pertains to studying new effective mechanisms that limit neuronal dysfunction associated with ischemic and hemorrhagic stroke, Alzheimer disease (AD), aging, and various other neurological disorders. His objective is focused on understanding the protective role of heme metabolites in the brain using cellular/molecular techniques and various models of stroke, Alzheimer disease, and aging. New knowledge is gained specifically by investigating the action and the role of activity of the heme oxygenase enzyme and its unique bioactive metabolites: carbon monoxide, iron, biliverdin, and bilirubin. His overall goal is to slow down the progression of the disease and ultimately stop it.

Winning the Chairman Award for Outstanding Service and Dedication at the Department of Anesthesiology, University of Florida, is among his many accomplishments. He is involved in many ad hoc journal peer review activities and sits on the editorial board of multiple journals, including Frontiers in Neuroscience, Neurotoxicity Research, Faculty of 1000, World Journal of Cardiology, International Journal of Clinical and Experimental Medicine, Translational Neuroscience, and International Journal of Clinical Anesthesiology.

Dr. Doré is a well-published author with over 126 scholarly publications across 13 different disciplines. He has received many grant awards funding his research and has filed patents for five intellectual properties.

Honors & Awards

University Term Professor
2017 · UF-College of Medicine
Exemplary Teacher Award
2015 · UF-College of Medicine
Fellow of the AHA Association
2015 · American Heart and Stroke Association, Stroke Council
UF Master Mentor
2014 · UF-College of Medicine
2011 Recipient of the 2011 Chair Award
2011 · Dept of Anesthesiology, College of Medicine, UF
Recipient of the Niels Lassen Award at Brain 01
2001 · Intl Soc. for Cereb Blood Flow & Metab

Clinical Profile

Areas of Interest
  • Acute Ischemic Stroke
  • Alzheimer disease
  • Cerebrovascular occlusive disease
  • Exchange transfusion
  • Hypoxic-Ischemic Encephalopathy (HIE)
  • Subarachnoid hemorrhage
  • Traumatic Brain Injury

Publications

2016 American Journal of Physiology-Heart and Circulatory Physiology
2015 American Journal of Physiology-Heart and Circulatory Physiology
2015 Frontiers in Cellular Neuroscience
2009 Journal of Cerebral Blood Flow and Metabolism
2008 New Trends in Alzheimer and Parkinson Disorders
2007 Journal of Cerebral Blood Flow and Metabolism
2003 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2001 The Corsini Encyclopedia of Psychology and Behavioral Science

Grants

April 2019ACTIVE
Potential stroke therapeutic efficacy of FumET-CORM through the Nrf2 pathway
NATL INST OF HLTH NINDS · Principal Investigator
July 2018ACTIVE
Is CO sufficient to reduce delayed cerebral ischemia and provide neuroprotection after SAH?
AMER HEART ASSOCIATION · Mentor
January 2018ACTIVE
CO therapeutic role and potential mechanism in TBI
NATL INST OF HLTH NINDS · Principal Investigator
October 2017ACTIVE
Neuroprotection after SAH? Genetic Predictors of Unruptured Intracranial Aneurysm Growth Behavior and quantitative Imaging
BRAIN ANEURYSM FOU · Principal Investigator
June 2017 – December 2017
FAER MSARF 2017 for Jeffery P. Fleming
FOU FOR ANESTHESIA EDU AND RES · Principal Investigator
January 2017ACTIVE
To Investigate the Unique Role and Putative Mechanism of CD163-mediated Protection against ICH
AMER HEART ASSOCIATION · Principal Investigator
August 2016 – July 2019
Regulation and Implication of Hemoglobin Clearance in Subarachnoid Hemorrhagic Patients
NATL INST OF HLTH NINDS · Principal Investigator
July 2016 – June 2018
Which brain cells are responsible for the neuroprotection elicited by Nrf2 induction?
AMER HEART ASSOCIATION · Principal Investigator
July 2016 – June 2017
AHA 2016 Scientific Councils Student Scholarship in Cerebrovascular Disease
AMER HEART ASSOCIATION · Mentor
May 2016 – December 2016
FAER MSARF 2016 for Avigeet Gupta
FOU FOR ANESTHESIA EDU AND RES · Principal Investigator
March 2014 – July 2016
Role of Haptoglobin and CD163 in brain hemorrhage
NATL INST OF HLTH NINDS · Principal Investigator
September 2012 – September 2018
Better Understanding of the Neuroprotective Mechanisms of Korean Ginseng in Stroke
NATL CTR FOR COMPLEM AND INTEGRATIVE HLT · Principal Investigator
September 2010 – August 2016
Role of Prostaglandin Receptors in Stroke
NATL INST OF HLTH NINDS · Principal Investigator
July 2010 – June 2019
Stroke and Neuroinflammation
FL CLINICAL PRACTICE ASSO · Principal Investigator
July 2006ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
FL DEPT OF HLTH · Project Manager

Education

1999
Postdoctoral, Neuroscience
John Hopkins University
1996
Postdoctoral, Psychiatry
McGill University
1994
PhD, Biomedical Sciences
University of Montreal
1990
MS, Pharmacology
University of Quebec