Sylvain Doré, PhD, FAHA
Professor, Anesthesiology, Neurology, Psychiatry, Pharmaceutics, Neuroscience; Director, Anesthesiology Research Programs
About Sylvain Doré
Sylvain Doré, PhD, FAHA is a Professor of Anesthesiology, as well as a Professor of Neurology, Psychiatry, Pharmaceutics, and Neuroscience, at the University of Florida, College of Medicine.
Dr. Doré attained his PhD in Biomedical Science from the University of Montreal and an MS degree in Pharmacology at the University of Quebec. He received post-PhD training in Psychiatry at McGill University, as well as post-PhD training in Neuroscience under the supervision of Dr. Solomon H Snyder at Johns Hopkins University.
Dr. Doré’s research pertains to studying new effective mechanisms that limit neuronal dysfunction associated with ischemic and hemorrhagic stroke, traumatic brain injury, Alzheimer disease (AD), aging, and various other neurological disorders. His objective is focused on understanding the protective role of heme metabolites in the brain using cellular/molecular techniques and various models of stroke, Alzheimer disease, and dementia. New knowledge is gained specifically by investigating the action and the role of activity of the heme oxygenase enzyme and its unique bioactive metabolites: carbon monoxide, iron, biliverdin, and bilirubin. He has also conducted pioneered work in the field of pro-inflammatory prostaglandins and the GPRR receptors. His overall goal is to slow down the progression of the disease and ultimately stop it.
Winning the Chairman Award for Outstanding Service and Dedication at the Department of Anesthesiology, University of Florida, is among his many accomplishments. He is involved in many ad hoc journal peer review activities and sits on the editorial board of multiple journals, including Frontiers in Neuroscience, Neurotoxicity Research, Faculty of 1000, World Journal of Cardiology, International Journal of Clinical and Experimental Medicine, Translational Neuroscience, and International Journal of Clinical Anesthesiology.
Dr. Doré is a well-published author with over 160 scholarly publications across 13 different disciplines. He has received many grant awards funding his research and has filed patents for five intellectual properties.
Related Links:
Accomplishments
Member, Board of Trustees
2021
·
University of Florida
Chair-elect, Faculty Senate
2020
·
University of Florida
University Term Professor
2017
·
UF-College of Medicine
Exemplary Teacher Award
2015
·
UF-College of Medicine
Fellow of the AHA Association
2015
·
American Heart and Stroke Association, Stroke Council
UF Master Mentor
2014
·
UF-College of Medicine
2011 Recipient of the 2011 Chair Award
2011
·
Dept of Anesthesiology, College of Medicine, UF
Recipient of the Niels Lassen Award at Brain 01
2001
·
Intl Soc. for Cereb Blood Flow & Metab
Teaching Profile
Courses Taught
2011-2017,2019
GMS6029 Brain Journal Club
2013,2016-2017
GMS6750 Molecular Pathobiology of Neural Disease
2013-2014
GMS6024 Princ Neuroscience 4
2013
GMS7794 Neuroscience Seminar
2021
BSC4912 Advanced Mentored Research in Biology
Clinical Profile
Areas of Interest
- Acute Ischemic Stroke
- Alzheimer disease
- Cerebral amyloid angiopathy
- Cerebrovascular occlusive disease
- Concussion
- Exchange transfusion
- Hypoxic-Ischemic Encephalopathy (HIE)
- Sickle cell disease
- Subarachnoid hemorrhage
- Traumatic Brain Injury
- Vascular dementia
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-3771-5109
Areas of Interest
- Prevention of Brain Injury
- Clinical Translational Neuroscience
- Natural products
- Translational drug development
Publications
2023
Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options
Translational Stroke Research.
[DOI] 10.1007/s12975-023-01123-x.
2023
Role of CRF and the hypothalamic‐pituitary‐adrenal axis in stroke: revisiting temporal considerations and targeting a new generation of therapeutics
The FEBS Journal.
290(8):1986-2010
[DOI] 10.1111/febs.16380.
2023
Therapeutic Potential of Music-Based Interventions on the Stress Response and Neuroinflammatory Biomarkers in COVID-19: A Review
Music & Science.
6
[DOI] 10.1177/20592043221135808.
2022
A Genome-Wide Association Study of Outcome After Aneurysmal Subarachnoid Haemorrhage: Discovery Analysis
Translational Stroke Research.
[DOI] 10.1007/s12975-022-01095-4.
2022
Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance
Brain Sciences.
12(6)
[DOI] 10.3390/brainsci12060742.
[PMID] 35741627.
2022
Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol
Translational Stroke Research.
13(4):565-576
[DOI] 10.1007/s12975-021-00978-2.
[PMID] 34988871.
2022
Influence of Haptoglobin Polymorphism on Stroke in Sickle Cell Disease Patients
Genes.
13(1)
[DOI] 10.3390/genes13010144.
[PMID] 35052484.
2021
Association of Serum Bilirubin with the Severity and Outcomes of Intracerebral Hemorrhages
Antioxidants.
10(9)
[DOI] 10.3390/antiox10091346.
[PMID] 34572977.
2021
Carbon Monoxide Therapy Using Hybrid Carbon Monoxide-Releasing/Nrf2-Inducing Molecules through a Neuroprotective Lens
Chemistry.
3(3):800-817
[DOI] 10.3390/chemistry3030057.
2021
Cerebral Venous Thrombosis and Hypercoagulability Associated With In Vitro Fertilization
Stroke.
52(9)
[DOI] 10.1161/strokeaha.121.035962.
2021
Critical Role of Hemopexin Mediated Cytoprotection in the Pathophysiology of Sickle Cell Disease
International Journal of Molecular Sciences.
22(12)
[DOI] 10.3390/ijms22126408.
[PMID] 34203861.
2021
Haptoglobin Genotype Affects Inflammation after Aneurysmal Subarachnoid Hemorrhage
Current Neurovascular Research.
17(5):652-659
[DOI] 10.2174/1567202617666201214104623.
2021
Nrf2 as a therapeutic target in ischemic stroke
Expert Opinion on Therapeutic Targets.
1-4
[DOI] 10.1080/14728222.2021.1890716.
2021
Potential Role of Soluble Toll-like Receptors 2 and 4 as Therapeutic Agents in Stroke and Brain Hemorrhage
International Journal of Molecular Sciences.
22(18)
[DOI] 10.3390/ijms22189977.
[PMID] 34576137.
2021
Soluble Receptors Affecting Stroke Outcomes: Potential Biomarkers and Therapeutic Tools
International Journal of Molecular Sciences.
22(3)
[DOI] 10.3390/ijms22031108.
[PMID] 33498620.
2020
Blood-Related Toxicity after Traumatic Brain Injury: Potential Targets for Neuroprotection
Molecular Neurobiology.
57(1):159-178
[DOI] 10.1007/s12035-019-01766-8.
2020
Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke
PLOS ONE.
15(1)
[DOI] 10.1371/journal.pone.0227624.
[PMID] 31945776.
2020
Effect of Experimental Ischemic Stroke and PGE2 EP1 Selective Antagonism in Alzheimer’s Disease Mouse Models.
Journal of Alzheimer's disease : JAD.
74(1):173-187
[DOI] 10.3233/JAD-191069.
[PMID] 31985468.
2020
Nrf2 Deficiency Exacerbates Cognitive Impairment and Reactive Microgliosis in a Lipopolysaccharide-Induced Neuroinflammatory Mouse Model.
Cellular and molecular neurobiology.
40(7):1185-1197
[DOI] 10.1007/s10571-020-00807-4.
[PMID] 32170572.
2020
Reactive Gliosis Contributes to Nrf2-Dependent Neuroprotection by Pretreatment with Dimethyl Fumarate or Korean Red Ginseng Against Hypoxic-Ischemia: Focus on Hippocampal Injury
Molecular Neurobiology.
57(1):105-117
[DOI] 10.1007/s12035-019-01760-0.
[PMID] 31494826.
2020
Role of the PGE
2
receptor subtypes EP1, EP2, and EP3 in repetitive traumatic brain injury
CNS Neuroscience & Therapeutics.
26(6):628-635
[DOI] 10.1111/cns.13228.
[PMID] 31617678.
2019
Bilirubin and Ischemic Stroke: Rendering the Current Paradigm to Better Understand the Protective Effects of Bilirubin
Molecular Neurobiology.
56(8):5483-5496
[DOI] 10.1007/s12035-018-1440-y.
2019
Carbon monoxide attenuates vasospasm and improves neurobehavioral function after subarachnoid hemorrhage.
Archives of biochemistry and biophysics.
676
[DOI] 10.1016/j.abb.2019.108117.
[PMID] 31560866.
2019
Haptoglobin genotype and aneurysmal subarachnoid hemorrhage
Neurology.
[DOI] 10.1212/wnl.0000000000007397.
2019
Haptoglobin genotype and aneurysmal subarachnoid hemorrhage
Neurology.
[DOI] 10.1212/wnl.0000000000007397.
2019
Nrf2 Plays an Essential Role in Long-Term Brain Damage and Neuroprotection of Korean Red Ginseng in a Permanent Cerebral Ischemia Model
Antioxidants.
8(8)
[DOI] 10.3390/antiox8080273.
[PMID] 31382635.
2019
Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism.
Free radical biology & medicine.
131:98-114
[DOI] 10.1016/j.freeradbiomed.2018.11.017.
[PMID] 30458277.
2019
Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes.
Experimental neurology.
317:22-33
[DOI] 10.1016/j.expneurol.2019.01.011.
[PMID] 30790555.
2018
A Pilot Study of Inhaled CO Therapy in Neonatal Hypoxia-Ischemia: Carboxyhemoglobin Concentrations and Brain Volumes.
Frontiers in pediatrics.
6
[DOI] 10.3389/fped.2018.00120.
[PMID] 29765933.
2018
Genetic Deletion of PGF2α-FP Receptor Exacerbates Brain Injury Following Experimental Intracerebral Hemorrhage.
Frontiers in neuroscience.
12
[DOI] 10.3389/fnins.2018.00556.
[PMID] 30233287.
2018
The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
38(2):262-273
[DOI] 10.1177/0271678X17701459.
[PMID] 28358264.
2018
Unique Properties Associated with the Brain Penetrant Iron Chelator HBED Reveal Remarkable Beneficial Effects after Brain Trauma.
Journal of neurotrauma.
36(1):43-53
[DOI] 10.1089/neu.2017.5617.
[PMID] 29743006.
2017
Efficacy of Laropiprant in Minimizing Brain Injury Following Experimental Intracerebral Hemorrhage.
Scientific reports.
7(1)
[DOI] 10.1038/s41598-017-09994-5.
[PMID] 28842638.
2016
Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.
Journal of neuroinflammation.
13
[DOI] 10.1186/s12974-016-0490-1.
[PMID] 26831741.
2016
PGE2-EP3 signaling exacerbates intracerebral hemorrhage outcomes in 24-mo-old mice.
American journal of physiology. Heart and circulatory physiology.
310(11):H1725-34
[DOI] 10.1152/ajpheart.00638.2015.
[PMID] 27084388.
2015
Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
Scientific reports.
5
[DOI] 10.1038/srep17956.
[PMID] 26648273.
2015
Efficacy of prophylactic flavan-3-ol in permanent focal ischemia in 12-mo-old mice.
American journal of physiology. Heart and circulatory physiology.
308(6):H583-91
[DOI] 10.1152/ajpheart.00239.2014.
[PMID] 25576625.
2015
Genetic deletion of the prostaglandin E2 E prostanoid receptor subtype 3 improves anatomical and functional outcomes after intracerebral hemorrhage.
The European journal of neuroscience.
41(10):1381-91
[DOI] 10.1111/ejn.12909.
[PMID] 25847406.
2015
Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage.
Proceedings of the National Academy of Sciences of the United States of America.
112(4):1155-60
[DOI] 10.1073/pnas.1412833112.
[PMID] 25583472.
2015
Intracerebral hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor.
BMC neuroscience.
16
[DOI] 10.1186/s12868-015-0182-2.
[PMID] 26232001.
2015
Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity.
Neurotoxicology.
46:53-9
[DOI] 10.1016/j.neuro.2014.10.012.
[PMID] 25451967.
2015
Prostaglandin E2 EP2 receptor deletion attenuates intracerebral hemorrhage-induced brain injury and improves functional recovery.
ASN neuro.
7(2)
[DOI] 10.1177/1759091415578713.
[PMID] 25873308.
2014
Ep1 Deletion Exacerbate Hemorrhagic Injury By Delaying Microglial Phagocytosis
Cerebrovascular Diseases.
38(1)
2014
Ginseng: a promising neuroprotective strategy in stroke.
Frontiers in cellular neuroscience.
8
[DOI] 10.3389/fncel.2014.00457.
[PMID] 25653588.
2014
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke.
Journal of neurochemistry.
129(1):130-42
[DOI] 10.1111/jnc.12607.
[PMID] 24225006.
2014
Role of the prostaglandin E2 EP1 receptor in traumatic brain injury.
PloS one.
9(11)
[DOI] 10.1371/journal.pone.0113689.
[PMID] 25426930.
2014
Therapeutic Potential of the Prostaglandin E2 Ep1 Receptor in Traumatic Brain Injury
Journal of Neurotrauma.
31(12)
2013
Cathepsin G-Dependent Modulation of Platelet Thrombus Formation in Vivo By Blood Neutrophils
PLoS One.
8(8)
[DOI] 10.1371/journal.pone.0071447.
[PMID] 23940756.
2013
Effect of Temperature On Co Sensing Response in Air Ambient By Using Zno Nanorod-Gated Algan/Gan High Electron Mobility Transistors
Sensors and Actuators B-Chemical.
176:708-712
[DOI] 10.1016/j.snb.2012.10.051.
2013
Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models.
ACS chemical neuroscience.
4(8):1151-62
[DOI] 10.1021/cn400094w.
[PMID] 23758534.
2013
PGE2 EP1 receptor deletion attenuates 6-OHDA-induced Parkinsonism in mice: old switch, new target.
Neurotoxicity research.
23(3):260-6
[DOI] 10.1007/s12640-013-9381-8.
[PMID] 23385625.
2013
Prostaglandin F2 Alpha Fp Receptor Antagonist Improves Outcomes After Experimental Traumatic Brain Injury
Journal of Neurotrauma.
30
2013
Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury.
Journal of neuroinflammation.
10
[DOI] 10.1186/1742-2094-10-132.
[PMID] 24172576.
2013
Role of PGE₂ EP1 receptor in intracerebral hemorrhage-induced brain injury.
Neurotoxicity research.
24(4):549-59
[DOI] 10.1007/s12640-013-9410-7.
[PMID] 23824501.
2012
Carbon Monoxide Detection Sensitivity of Zno Nanorod-Gated Algan/Gan High Electron Mobility Transistors in Different Temperature Environments
Journal of Vacuum Science & Technology B.
30(1):1-4
[DOI] 10.1116/1.3672010.
2012
Histone Deacetylase Inhibition Activates Transcription Factor Nrf2 and Protects Against Cerebral Ischemic Damage
Free Radical Biology and Medicine.
52(5):928-936
[DOI] 10.1016/j.freeradbiomed.2011.12.006.
[PMID] 22226832.
2012
PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer’s disease.
Neurobiology of aging.
33(9):2215-9
[DOI] 10.1016/j.neurobiolaging.2011.09.017.
[PMID] 22015313.
2012
Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity.
Neurobiology of disease.
48(1):58-65
[DOI] 10.1016/j.nbd.2012.06.003.
[PMID] 22709986.
2011
Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia.
Stroke.
42(9):2605-10
[DOI] 10.1161/STROKEAHA.110.607101.
[PMID] 21852618.
2011
Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins.
Nutritional neuroscience.
14(5):226-36
[DOI] 10.1179/1476830511Y.0000000013.
[PMID] 22005287.
2011
Effect of Temperature On Co Detection Sensitivity of Zno Nanorod-Gated Algan/Gan High Electron Mobility Transistors
Applied Physics Letters.
99(14):1-3
[DOI] 10.1063/1.3647561.
2011
Fenoldopam preconditioning: Role of heme oxygenase-1 in protecting human tubular cells and rodent kidneys against cold-hypoxic injury
Transplantation.
91(2):176-182
[DOI] 10.1097/TP.0b013e3181fffff2.
[PMID] 21076374.
2011
Heme Oxygenase 1, Beneficial Role in Permanent Ischemic Stroke and in Gingko Biloba (Egb 761) Neuroprotection
Neuroscience.
180:248-255
[DOI] 10.1016/j.neuroscience.2011.02.031.
[PMID] 21334424.
2011
Myelin-associated glycoprotein protects neurons from excitotoxicity.
Journal of neurochemistry.
116(5):900-8
[DOI] 10.1111/j.1471-4159.2010.07069.x.
[PMID] 21214567.
2010
Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice.
Journal of neuroinflammation.
7
[DOI] 10.1186/1742-2094-7-42.
[PMID] 20673332.
2010
Death-associated protein kinase-mediated cell death modulated by interaction with DANGER.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
30(1):93-8
[DOI] 10.1523/JNEUROSCI.3974-09.2010.
[PMID] 20053891.
2010
Ecosystem Carbon Dioxide Fluxes After Disturbance in Forests of North America
Journal of Geophysical Research.
115
[DOI] 10.1029/2010JG001390.
2010
Importance of normothermia control in investigating delayed neuronal injury in mouse global ischemia model
Journal of Neuroscience Methods.
185(2):230-235
[DOI] 10.1016/j.jneumeth.2009.09.026.
[PMID] 19815029.
2010
Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer’s disease.
Experimental neurology.
223(2):359-65
[DOI] 10.1016/j.expneurol.2009.07.027.
[PMID] 19664621.
2010
Neuroprotective effect of HT008-1, a prescription of traditional Korean medicine, on transient focal cerebral ischemia model in rats.
Phytotherapy research : PTR.
24(8):1207-12
[DOI] 10.1002/ptr.2908.
[PMID] 20148407.
2010
Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia
Neuroscience.
170(1):317-323
[DOI] 10.1016/j.neuroscience.2010.06.060.
[PMID] 20621166.
2010
Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice.
Age (Dordrecht, Netherlands).
32(3):271-82
[DOI] 10.1007/s11357-010-9135-y.
[PMID] 20640551.
2010
Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1.
Experimental neurology.
224(1):325-9
[DOI] 10.1016/j.expneurol.2010.03.032.
[PMID] 20381489.
2010
Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
30(4):1413-6
[DOI] 10.1523/JNEUROSCI.4297-09.2010.
[PMID] 20107067.
2010
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
30(12):1951-61
[DOI] 10.1038/jcbfm.2010.53.
[PMID] 20442725.
2009
Cytosolic prostaglandin E synthase: expression patterns in control and Alzheimerâs disease brains
American Journal of Alzheimers Disease and Other Dementias.
24(1):46-51
[DOI] 10.1177/1533317508323655.
[PMID] 19001348.
2009
GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.
Neuron.
63(1):81-91
[DOI] 10.1016/j.neuron.2009.05.024.
[PMID] 19607794.
2009
Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia.
Neurobiology of disease.
35(2):264-9
[DOI] 10.1016/j.nbd.2009.05.010.
[PMID] 19465127.
2009
Heme-hemopexin complex attenuates neuronal cell death and stroke damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
29(5):953-64
[DOI] 10.1038/jcbfm.2009.19.
[PMID] 19277051.
2009
Lipocalin-prostaglandin D synthase is a critical beneficial factor in transient and permanent focal cerebral ischemia
Neuroscience.
160(1):248-254
[DOI] 10.1016/j.neuroscience.2009.02.039.
[PMID] 19254753.
2009
Low doses of carbon monoxide protect against experimental focal brain ischemia.
Neurotoxicity research.
15(2):133-7
[DOI] 10.1007/s12640-009-9014-4.
[PMID] 19384576.
2009
PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia.
Neurotoxicity research.
15(1):62-70
[DOI] 10.1007/s12640-009-9007-3.
[PMID] 19384589.
2009
Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia.
Journal of neuroimmunology.
208(1-2):87-93
[DOI] 10.1016/j.jneuroim.2009.01.015.
[PMID] 19203800.
2008
Elevated microsomal prostaglandin-E synthase-1 in Alzheimer’s disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
4(1):6-13
[DOI] 10.1016/j.jalz.2007.10.015.
[PMID] 18631945.
2008
Enhancing effect of HT008-1 on cognitive function and quality of life in cognitively declined healthy adults: a randomized, double-blind, placebo-controlled, trial.
Pharmacology, biochemistry, and behavior.
90(4):517-24
[DOI] 10.1016/j.pbb.2008.03.033.
[PMID] 18550156.
2008
Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls.
Journal of neuroimmunology.
195(1-2):81-7
[DOI] 10.1016/j.jneuroim.2008.01.014.
[PMID] 18353443.
2008
Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury.
Stroke.
39(12):3389-96
[DOI] 10.1161/STROKEAHA.108.523480.
[PMID] 18845796.
2008
Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage
Neuroscience.
155(4):1133-1141
[DOI] 10.1016/j.neuroscience.2008.07.004.
[PMID] 18674596.
2008
Neuroprotection and enhancement of spatial memory by herbal mixture HT008-1 in rat global brain ischemia model.
The American journal of Chinese medicine.
36(2):287-99
[PMID] 18457361.
2008
Neuroprotective role of heme oxygenase-2 in 6-hydroxydopamine-lesioned mouse
New Trends in Alzheimer and Parkinson Disorders.
201-208
2008
Prostacyclin receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery occlusion in mouse
Neuroscience.
156(4):1111-1117
[DOI] 10.1016/j.neuroscience.2008.07.073.
[PMID] 18790018.
2008
Role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymers.
American journal of physiology. Regulatory, integrative and comparative physiology.
295(2):R498-504
[DOI] 10.1152/ajpregu.00188.2008.
[PMID] 18495834.
2008
Selective blockade of PGE2 EP1 receptor protects brain against experimental ischemia and excitotoxicity, and hippocampal slice cultures against oxygen-glucose deprivation.
Neurotoxicity research.
14(4):343-51
[PMID] 19073437.
2008
The development of an improved preclinical mouse model of intracerebral hemorrhage using double infusion of autologous whole blood.
Brain research.
1222:214-21
[DOI] 10.1016/j.brainres.2008.05.058.
[PMID] 18586227.
2007
Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice.
Journal of neuroscience research.
85(11):2433-40
[PMID] 17600836.
2007
Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage.
Brain : a journal of neurology.
130(Pt 6):1643-52
[PMID] 17525142.
2007
Inflammation after intracerebral hemorrhage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
27(5):894-908
[PMID] 17033693.
2007
Optimized protocol to reduce variable outcomes for the bilateral common carotid artery occlusion model in mice.
Journal of neuroscience methods.
166(1):73-80
[PMID] 17692388.
2007
PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury.
The European journal of neuroscience.
26(1):73-8
[PMID] 17573924.
2007
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice.
Free radical biology & medicine.
43(3):408-14
[PMID] 17602956.
2007
Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury
Neuroscience.
147(1):53-59
[DOI] 10.1016/j.neuroscience.2007.02.066.
[PMID] 17507167.
2007
Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury.
Journal of neuroimmunology.
184(1-2):172-9
[PMID] 17275922.
2006
1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia.
The European journal of neuroscience.
23(1):35-42
[PMID] 16420413.
2006
Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin.
American journal of physiology. Heart and circulatory physiology.
290(3):H1027-37
[PMID] 16214847.
2006
GPCR antagonists as an alternative to COX-2 inhibitors: a case for the PGE2 EP1 receptor.
Trends in pharmacological sciences.
27(9):458-60
[PMID] 16870271.
2006
Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage.
Neurobiology of disease.
22(3):473-6
[PMID] 16459095.
2006
Heme oxygenase-1 protects brain from acute excitotoxicity
Neuroscience.
141(4):1703-1708
[DOI] 10.1016/j.neuroscience.2006.05.035.
[PMID] 16828975.
2006
Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage.
Toxicological sciences : an official journal of the Society of Toxicology.
89(1):265-70
[PMID] 16237196.
2006
Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity.
Journal of neurotrauma.
23(12):1895-903
[PMID] 17184197.
2005
Catalytically inactive heme oxygenase-2 mutant is cytoprotective.
Free radical biology & medicine.
39(4):558-64
[PMID] 16043027.
2005
Characterization of heme oxygenase in adult rodent platelets.
Current neurovascular research.
2(2):163-8
[PMID] 16181109.
2005
Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity.
Free radical biology & medicine.
38(1):85-92
[PMID] 15589375.
2005
Expression of prostaglandin E2 synthases in mouse postnatal cortical neurons.
Annals of the New York Academy of Sciences.
1053:460-71
[PMID] 16179554.
2005
Prostaglandin EP4 receptor agonist protects against acute neurotoxicity.
Brain research.
1066(1-2):71-7
[PMID] 16360658.
2005
Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure.
The European journal of neuroscience.
22(9):2199-206
[PMID] 16262658.
2005
Stroke outcomes in mice lacking the genes for neuronal heme oxygenase-2 and nitric oxide synthase.
Current neurovascular research.
2(1):23-7
[PMID] 16181097.
2005
Unique properties of polyphenol stilbenes in the brain: more than direct antioxidant actions; gene/protein regulatory activity.
Neuro-Signals.
14(1-2):61-70
[PMID] 15956815.
2004
Differential roles of neuronal and endothelial nitric oxide synthase during carrageenan-induced inflammatory hyperalgesia
Neuroscience.
128(2):421-430
[DOI] 10.1016/j.neuroscience.2004.06.038.
[PMID] 15350652.
2003
Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2-deficient mice.
American journal of physiology. Regulatory, integrative and comparative physiology.
285(1):R222-30
[PMID] 12663258.
2003
Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction.
Annals of neurology.
54(2):155-62
[PMID] 12891667.
2003
Potential mechanism by which resveratrol, a red wine constituent, protects neurons.
Annals of the New York Academy of Sciences.
993:276-86; discussion 287
[PMID] 12853318.
2003
Prostaglandins of J series control heme oxygenase expression: potential significance in modulating neuroinflammation.
Annals of the New York Academy of Sciences.
993:208-16; discussion 287
[PMID] 12853315.
2003
Regulation of heme oxygenase expression by cyclopentenone prostaglandins.
Experimental biology and medicine (Maywood, N.J.).
228(5):499-505
[PMID] 12709576.
2002
Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer’s disease.
Free radical biology & medicine.
32(12):1276-82
[PMID] 12057765.
2002
Induction of heme oxygenase 1 by Ginkgo biloba in neuronal cultures and potential implications in ischemia.
Cellular and molecular biology (Noisy-le-Grand, France).
48(6):647-53
[PMID] 12396075.
2001
Potential role of Insulin-like Growth Factor-I in learning and memory processes
The Corsini Encyclopedia of Psychology and Behavioral Science.
2:728-733
2000
Alteration of expression levels of neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA in the hippocampi and cortices of young and aged cognitively unimpaired and impaired Long-Evans rats
Neuroscience.
100(4):769-775
[DOI] 10.1016/S0306-4522(00)00316-X.
[PMID] 11036210.
2000
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer’s disease
Neuron.
28(2):461-473
[DOI] 10.1016/S0896-6273(00)00125-2.
[PMID] 11144356.
2000
Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia
Neuroscience.
99(4):587-592
[DOI] 10.1016/S0306-4522(00)00216-5.
[PMID] 10974422.
2000
Insulin-like growth factor-I (IGF-1): a neuroprotective factor acting via the Akt kinase pathway
Journal of Neural Transmission.
60(60):261-272
[PMID] 11205145.
2000
Insulin-like growth factor-I (IGF-1): a neuroprotective factor acting via the Akt kinase pathway
Journal of Neural Transmission.
60:S261-S272
2000
Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer’s disease and stroke
Pharmaceutica Acta Helvetiae.
74(2-3):273-280
[PMID] 10812969.
2000
The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by Beta-amyloid
European Journal of Neuroscience.
12(6):1882-1890
[DOI] 10.1046/j.1460-9568.2000.00069.x.
[PMID] 10886329.
1999
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
Proceedings of the National Academy of Sciences.
96(5):2445-2450
[DOI] 10.1073/pnas.96.5.2445.
[PMID] 10051662.
1999
Haem oxygenase-1 prevents cell death by regulating cellular iron
Nature cell biology.
1(3):152-157
[PMID] 10559901.
1999
Heme oxygenase-2 is neuroprotective in cerebral ischemia
Molecular Medicine.
5(10):656-663
[PMID] 10602774.
1999
Impact of neonatal kainate treatment on hippocampal insulin-like growth factor receptors
Neuroscience.
91(3):1035-1043
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[PMID] 10391481.
1999
Neuroprotective action of bilirubin against oxidative stress in primary hippocampal cultures
Annals of the New York Academy of Sciences.
890:167-172
[DOI] 10.1111/j.1749-6632.1999.tb07991.x.
[PMID] 10668423.
1999
Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons.
Annals of the New York Academy of Sciences.
890:356-64
[PMID] 10668442.
1998
Autoradiographic localization of growth factor receptors in brain tissue sections and cultured neurons: Insulin-like Growth Factors as a prototypical example
Current Protocols in Pharmacology.
8.2:1-17
1997
Distribution and levels of [125I]IGF-I, [125I]IGF-II and [125I]insulin receptor binding sites in the hippocampus of aged memory-unimpaired and -impaired rats
Neuroscience.
80(4):1033-1040
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1997
Insulin-like growth factor I protects and rescues hippocampal neurons against Beta-amyloid and human amylin-induced toxicity
Proceedings of the National Academy of Sciences.
94(9):4772-4777
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1997
Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation.
Proceedings of the National Academy of Sciences of the United States of America.
94(25):14054-9
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1997
Presence and differential internalization of two distinct insulin-like growth factor receptors in rat hippocampal neurons
Neuroscience.
78(2):373-383
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1997
Prostaglandin E2 stimulates insulin-like growth factor binding protein-4 expression and synthesis in cultured human articular chondrocytes. Possible mediation by Ca2+-calmodulin regulated processes
Journal of Cellular Biochemistry.
65(3):408-419
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1997
Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases.
Trends in neurosciences.
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1997
Systemic administration of kainic acid induces selective time dependent decrease in [125I]insulin-like growth factor I, [125I]insulin-like growth factor II and [125I]insulin receptor binding sites in adult rat hippocampal formation
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Utilization of Insulin-like Growth Factor-I for the treatment of neurological disorders
M S-Medecine Sciences.
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Distribution and levels of insulin-like growth factor (IGF-I and IGF-II) and insulin receptor binding sites in the spinal cords of amyotrophic lateral sclerosis (ALS) patients
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1996
IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients
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1996
Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: Identification of an effector autocrine loop involving insulin-like growth factor I
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Prostaglandin E2 up-regulates insulin-like growth factor binding protein-3 expression and synthesis in human articular chondrocytes by a cAMP-independent pathway: Role of calcium and protein kinase A and C
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Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 but are unresponsive to its stimulation: Possible role of IGF-1 binding proteins
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Grants
Sep 2022
ACTIVE
Molecular effects of metformin, PKR and TBI on C9orf72 ALS/FTD
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2020
ACTIVE
A Stress and Pain Self-management m-Health App for Adult Outpatients with Sickle Cell Disease
Role: Project Manager
Funding: NATL INST OF HLTH NINR
Aug 2020
ACTIVE
Testing brain penetrant iron chelators and investigating putative clearance pathway in ICH
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Aug 2019
ACTIVE
Neuroprotective mechanism of DMF/MMF associated with CAA-related pathology after TBI
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Apr 2019
– Mar 2023
Potential stroke therapeutic efficacy of FumET-CORM through the Nrf2 pathway
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2018
– Jun 2020
Is CO sufficient to reduce delayed cerebral ischemia and provide neuroprotection after SAH?
Role: Other
Funding: AMER HEART ASSOCIATION
Jan 2018
– Dec 2020
CO therapeutic role and potential mechanism in TBI
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Oct 2017
– Sep 2019
Neuroprotection after SAH? Genetic Predictors of Unruptured Intracranial Aneurysm Growth Behavior and quantitative Imaging
Role: Principal Investigator
Funding: BRAIN ANEURYSM FOU
Jun 2017
– Dec 2017
FAER MSARF 2017 for Jeffery P. Fleming
Role: Principal Investigator
Funding: FOU FOR ANESTHESIA EDU AND RES
Jan 2017
– Dec 2019
To Investigate the Unique Role and Putative Mechanism of CD163-mediated Protection against ICH
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Aug 2016
– Jul 2019
Regulation and Implication of Hemoglobin Clearance in Subarachnoid Hemorrhagic Patients
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2016
– Jun 2018
Which brain cells are responsible for the neuroprotection elicited by Nrf2 induction?
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jul 2016
– Jun 2017
AHA 2016 Scientific Councils Student Scholarship in Cerebrovascular Disease
Role: Other
Funding: AMER HEART ASSOCIATION
May 2016
– Dec 2016
FAER MSARF 2016 for Avigeet Gupta
Role: Principal Investigator
Funding: FOU FOR ANESTHESIA EDU AND RES
Mar 2014
– Jul 2016
Role of Haptoglobin and CD163 in brain hemorrhage
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2012
– Sep 2018
Better Understanding of the Neuroprotective Mechanisms of Korean Ginseng in Stroke
Role: Principal Investigator
Funding: NATL CTR FOR COMPLEM AND INTEGRATIVE HLT
Sep 2010
– Aug 2016
Role of Prostaglandin Receptors in Stroke.
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2010
– Jun 2019
Stroke and Neuroinflammation
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO
Jul 2006
ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH
Education
Postdoctoral, Neuroscience
1999
·
John Hopkins University
Postdoctoral, Psychiatry
1996
·
McGill University
PhD, Biomedical Sciences
1994
·
University of Montreal
MS, Pharmacology
1990
·
University of Quebec
Contact Details
Phones:
- Business:
- (352) 273-9663
Emails:
- Business:
- sdore@ufl.edu
Addresses:
- Business Mailing:
-
1345 SW Center Drive
GAINESVILLE FL 32610 - Business Street:
-
IN NEURODEGENERATIVE DISEASE
1275 CENTER DR, BMS J493
CENTER FOR TRANSLATIONAL RESEARCH
GAINESVILLE FL 32608