Sylvain Doré

Sylvain Doré, PhD, FAHA

Professor, Anesthesiology, Neurology, Psychiatry, Pharmaceutics, Neuroscience; Director, Anesthesiology Research Programs

Department: MD-ANESTHESIOLOGY-GENERAL
Business Phone: (352) 273-9663
Business Email: sdore@ufl.edu

About Sylvain Doré

Sylvain Doré, PhD, FAHA is a Professor of Anesthesiology, as well as a Professor of Neurology, Psychiatry, Pharmaceutics, and Neuroscience, at the University of Florida, College of Medicine.

Dr. Doré attained his PhD in Biomedical Science from the University of Montreal and an MS degree in Pharmacology at the University of Quebec. He received post-PhD training in Psychiatry at McGill University, as well as post-PhD training in Neuroscience under the supervision of Dr. Solomon H Snyder at Johns Hopkins University.

Dr. Doré’s research pertains to studying new effective mechanisms that limit neuronal dysfunction associated with ischemic and hemorrhagic stroke, traumatic brain injury, Alzheimer disease (AD), aging, and various other neurological disorders. His objective is focused on understanding the protective role of heme metabolites in the brain using cellular/molecular techniques and various models of stroke, Alzheimer disease, and dementia. New knowledge is gained specifically by investigating the action and the role of activity of the heme oxygenase enzyme and its unique bioactive metabolites: carbon monoxide, iron, biliverdin, and bilirubin. He has also conducted pioneered work in the field of pro-inflammatory prostaglandins and the GPRR receptors. His overall goal is to slow down the progression of the disease and ultimately stop it.

Winning the Chairman Award for Outstanding Service and Dedication at the Department of Anesthesiology, University of Florida, is among his many accomplishments. He is involved in many ad hoc journal peer review activities and sits on the editorial board of multiple journals, including Frontiers in Neuroscience, Neurotoxicity Research, Faculty of 1000, World Journal of Cardiology, International Journal of Clinical and Experimental Medicine, Translational Neuroscience, and International Journal of Clinical Anesthesiology.

Dr. Doré is a well-published author with over 160 scholarly publications across 13 different disciplines. He has received many grant awards funding his research and has filed patents for five intellectual properties.

Accomplishments

Chair-elect, Faculty Senate
2020 · University of Florida
University Term Professor
2017 · UF-College of Medicine
Fellow of the AHA Association
2015 · American Heart and Stroke Association, Stroke Council
Exemplary Teacher Award
2015 · UF-College of Medicine
UF Master Mentor
2014 · UF-College of Medicine
2011 Recipient of the 2011 Chair Award
2011 · Dept of Anesthesiology, College of Medicine, UF
Recipient of the Niels Lassen Award at Brain 01
2001 · Intl Soc. for Cereb Blood Flow & Metab

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-3771-5109

Areas of Interest
  • Prevention of Brain Injury
  • Clinical Translational Neuroscience
  • Natural products
  • Translational drug development

Publications

2020 Translational stroke research
2019 American journal of physiology. Cell physiology
2018 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
2018 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
2016 Methods in molecular biology (Clifton, N.J.)
2016 American journal of physiology. Heart and circulatory physiology
2015 American journal of physiology. Heart and circulatory physiology
2014 Frontiers in cellular neuroscience
2013 International journal of clinical anesthesiology
2010 The Journal of neuroscience : the official journal of the Society for Neuroscience
2010 The Journal of neuroscience : the official journal of the Society for Neuroscience
2010 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
2009 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
2008 New Trends in Alzheimer and Parkinson Disorders
2008 Alzheimer's & dementia : the journal of the Alzheimer's Association
2007 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
2006 Toxicological sciences : an official journal of the Society of Toxicology
2006 Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
2003 American journal of physiology. Regulatory, integrative and comparative physiology
2003 Experimental biology and medicine (Maywood, N.J.)
2001 The Corsini Encyclopedia of Psychology and Behavioral Science

Grants

Aug 2020 ACTIVE
Testing brain penetrant iron chelators and investigating putative clearance pathway in ICH
NATL INST OF HLTH NINDS · Principal Investigator
Aug 2019 ACTIVE
Neuroprotective mechanism of DMF/MMF associated with CAA-related pathology after TBI
US ARMY MED RES ACQUISITION · Principal Investigator
Apr 2019 ACTIVE
Potential stroke therapeutic efficacy of FumET-CORM through the Nrf2 pathway
NATL INST OF HLTH NINDS · Principal Investigator
Jul 2018 – Jun 2020
Is CO sufficient to reduce delayed cerebral ischemia and provide neuroprotection after SAH?
AMER HEART ASSOCIATION · Mentor
Jan 2018 ACTIVE
CO therapeutic role and potential mechanism in TBI
NATL INST OF HLTH NINDS · Principal Investigator
Oct 2017 – Sep 2019
Neuroprotection after SAH? Genetic Predictors of Unruptured Intracranial Aneurysm Growth Behavior and quantitative Imaging
BRAIN ANEURYSM FOU · Principal Investigator
Jun 2017 – Dec 2017
FAER MSARF 2017 for Jeffery P. Fleming
FOU FOR ANESTHESIA EDU AND RES · Principal Investigator
Jan 2017 – Dec 2019
To Investigate the Unique Role and Putative Mechanism of CD163-mediated Protection against ICH
AMER HEART ASSOCIATION · Principal Investigator
Aug 2016 – Jul 2019
Regulation and Implication of Hemoglobin Clearance in Subarachnoid Hemorrhagic Patients
NATL INST OF HLTH NINDS · Principal Investigator
Jul 2016 – Jun 2017
AHA 2016 Scientific Councils Student Scholarship in Cerebrovascular Disease
AMER HEART ASSOCIATION · Mentor
Jul 2016 – Jun 2018
Which brain cells are responsible for the neuroprotection elicited by Nrf2 induction?
AMER HEART ASSOCIATION · Principal Investigator
May 2016 – Dec 2016
FAER MSARF 2016 for Avigeet Gupta
FOU FOR ANESTHESIA EDU AND RES · Principal Investigator
Mar 2014 – Jul 2016
Role of Haptoglobin and CD163 in brain hemorrhage
NATL INST OF HLTH NINDS · Principal Investigator
Sep 2012 – Sep 2018
Better Understanding of the Neuroprotective Mechanisms
NATL CTR FOR COMPLEM AND INTEGRATIVE HLT · Principal Investigator
Sep 2010 – Aug 2016
Role of Prostaglandin Receptors in Stroke
NATL INST OF HLTH NINDS · Principal Investigator
Jul 2010 – Jun 2019
Stroke and Neuroinflammation
FL CLINICAL PRACTICE ASSO · Principal Investigator
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
FL DEPT OF HLTH · Project Manager

Education

Postdoctoral, Neuroscience
1999 · John Hopkins University
Postdoctoral, Psychiatry
1996 · McGill University
PhD, Biomedical Sciences
1994 · University of Montreal
MS, Pharmacology
1990 · University of Quebec

Contact Details

Phones:
Business:
(352) 273-9663
Emails:
Business:
sdore@ufl.edu