Cole Dooley

Cole Dooley, MD

Assistant Professor Of Anesthesiology

Business Phone: (352) 273-7094
Business Email:

About Cole Dooley

Cole Dooley, MD is an Assistant Professor of Anesthesiology in the divisions of Pediatric Anesthesiology and Perioperative Medicine. He received his medical degree from the University of Illinois College of Medicine in Peoria, IL. He did a transitional year internship at St. Vincent Hospital in Indianapolis, IN before joining the “Gator Nation” for his residency in Anesthesiology. He pursued a fellowship in Pediatric Anesthesia at Arkansas Children’s Hospital/UAMS in Little Rock, AR before coming back home to Gainesville. He is board-certified in General and Pediatric Anesthesiology.

Dr. Dooley currently serves as a question writer for the Pediatric Anesthesia MOCA minute. He is interested in simulation, process improvement, and preoperative anxiety management in the pediatric population. He is an active member in many organizations such as the Society for Pediatric Anesthesia, the Florida Society of Anesthesiologists, and the American Society of Anesthesiologists. He has completed mission trip work in Latin America for cleft lip and palate repair and is an authorized Spanish interpreter here at UF. During his free time he likes to travel, cook, and read. He is also a founder of a local non-profit, dedicating a lot of time to fundraising for pediatric cancer research in memory of his daughter.

Board Certifications

  • Anesthesiology
    American Board of Anesthesiology
  • Pediatric Anesthesiology
    American Board of Anesthesiology


A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.
Organic & biomolecular chemistry. 15(37):7796-7801 [DOI] 10.1039/c7ob01924f. [PMID] 28875208.
Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.
ACS combinatorial science. 18(1):51-64 [DOI] 10.1021/acscombsci.5b00126. [PMID] 26651386.
Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.
Journal of medicinal chemistry. 58(12):4905-17 [DOI] 10.1021/jm501637c. [PMID] 25996309.
Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.
European journal of medicinal chemistry. 92:270-81 [DOI] 10.1016/j.ejmech.2014.12.049. [PMID] 25559207.
Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin.
Bioorganic & medicinal chemistry letters. 24(18):4482-4485 [DOI] 10.1016/j.bmcl.2014.07.090. [PMID] 25168746.
Integrating computational and mixture-based screening of combinatorial libraries.
Journal of molecular modeling. 17(6):1473-82 [DOI] 10.1007/s00894-010-0850-1. [PMID] 20853183.
Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.
The AAPS journal. 12(3):318-29 [DOI] 10.1208/s12248-010-9191-3. [PMID] 20422341.
Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.
Bioorganic & medicinal chemistry. 17(15):5583-97 [DOI] 10.1016/j.bmc.2009.06.026. [PMID] 19576786.
Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
Journal of combinatorial chemistry. 10(1):3-19 [PMID] 18067268.
Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.
Bioorganic & medicinal chemistry letters. 16(16):4331-8 [PMID] 16750366.
Mixture-based synthetic combinatorial libraries.
Journal of medicinal chemistry. 42(19):3743-78 [PMID] 10508425.
Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.
Bioorganic & medicinal chemistry letters. 8(17):2273-8 [PMID] 9873527.
An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.
Science (New York, N.Y.). 266(5193):2019-22 [PMID] 7801131.


Fellowship, Pediatric Anesthesiology
2015 · Arkansas Children's Hospital
Residency, Anesthesiology
2015 · University of Florida
Internship, Transitional Medicine
2011 · St. Vincent Hospital
2010 · University of Illinois

Contact Details

(352) 273-7094
Business Mailing:
1345 SW Center Drive
Business Street:
1345 SW Center Drive, PO Box 100254
Gainesville FL 32610