Prodip K Bose, MD, PhD

My name is Prodip Bose, M.D., Ph.D., and I hold joint appointments as an associate professor in the Department of Anesthesiology, and the Department of Neurology here at the University of Florida. I earned my medical degree from the University of Dhaka. I completed my post-graduate medical training and fellowship in neurology and neurotrauma at the Case Western Reserve University School of Medicine, Ohio, and Northeastern Ohio Universities College of Medicine, Rootstown, Ohio. My Ph.D. in neuroscience was awarded by the University of Hong Kong College of Medicine.

In addition to my work as an associate professor, I am also dually appointed with the Malcom Randall VA Medical Center, where I’m the MRI and Translational Neurotrauma Rehabilitation Laboratory director. I also serve as the interim director of the Brain Rehabilitation Research Center, a national center of the VA Rehabilitation Research & Development located at the North Florida/South Georgia Veterans Health System.

My main areas of research are spinal cord injury, traumatic brain injury, and stroke. I’m currently the principal investigator on multiple active research grants funded by the US Department of Veterans Affairs, the Department of Defense, the National Institute of Health, and several other agencies. I’ve contributed numerous peer-reviewed manuscripts, book chapters, abstracts, and conference proceedings to the body of work in my field.

Recently, attention has been given to developing a research program in the area of iron chelator and Oxygen therapies aiming at reducing neuro-inflammation and enhancing neuroregeneration following neurotrauma (TBI and SCI), stroke, and Parkinson’s disease. The inflammatory burden initiated by injury/disease is further increased by free toxic iron derived from micro-bleeds which is known to act as a powerful promoter of chronic inflammation. Focus has been given to cellular and molecular neurobiology related to the therapies-induced recovery of disabilities (spasticity/rigidity-motor, anxiety-like behavior, cognitive, balance, and pain problems). The long-term focus of my laboratory research has been to understand the molecular-physiological-through-imagining (MRI)-behavioral neurobiology of motor, sensory and cognitive plasticity following pharmacotherapy and neurorehabilitation using preclinical (rodent) models of neurotrauma (spinal cord, traumatic brain injuries, and stroke), and neurodegenerative/neuro-autoimmune diseases (e.g., PD, MS, ALS). Research focus has been directed to mechanism-based research studies that involve the development and testing of innovative translational targeted pharmacological therapies in conjunction with other complementary therapies (e.g., programmed locomotor exercise, transcranial magnetic stimulation, electrical stimulation on acupuncture points, stem cell and gene therapy) aimed at inducing guided neuroplasticity and neuroregeneration, and ultimately reducing disabilities. Drug toxicological studies using behavioral, physiological, and histological measures are an integral part of this therapeutic initiative.

The research program in the Bose Laboratory is supported by funding from the US Department of Veterans Affairs (the list is not included here under the funding subheading), the Department of Defense (DoD), NIH, and several other funding agencies.

• Advanced MRI and stroke
• Post-Traumatic Stress Disorder
• Stroke
• Traumatic spinal cord injury
• traumatic brain injury