Prodip K Bose, MD, PhD

Prodip K. Bose, MD, Ph.D., is dually appointed with the University of Florida College of Medicine and the US Department of Veterans Affairs Health System (Malcom Randall VAMC). He currently holds joint appointments as an Associate Professor in the Department of Anesthesiology, College of Medicine, and the Department of Neurology in the College of Medicine and McKnight Brain Institute and the Department of Physiological Sciences.

At the Malcom Randall VA Medical Center, Dr. Bose is the MRI and Translational Neurotrauma Rehabilitation Laboratory director. He also serves as the Associate Director of the Brain Rehabilitation Research Center, a national center of the VA Rehabilitation Research & Development; and Deputy Associate Chief of Staff/Research & Development for the VMU, North Florida/South Georgia Veterans Health System; and a member of the Editorial Board of the Neural Regeneration Research journal.

Dr. Bose, whose main areas of research are spinal cord injury, traumatic brain injury, and stroke, is also a University of Florida Graduate Faculty in the College of Medicine Biomedical Sciences Program since 2001 and a member of several committees of the VA health system. He earned his medical degree from the University of Dhaka. He did a fellowship in Neurology and Neurotrauma at the Case Western Reserve University School of Medicine, Ohio, and Northeastern Ohio Universities College of Medicine, Rootstown, Ohio. His Ph.D. in Neuroscience was awarded by the University of Hong Kong College of Medicine.

Dr. Bose has contributed numerous peer-reviewed manuscripts, book chapters, abstracts, and conference proceedings to his field. He is currently a Principal Investigator and a Co-investigator on multiple active research grants. The research program is supported by funding from the US Department of Veterans Affairs, the Department of Defense (DoD), the National Institute of Health (NIH), and several other funding agencies.

Recently, attention has been given to developing a research program in the area of iron chelator and Oxygen therapies aiming at reducing neuro-inflammation and enhancing neuroregeneration following neurotrauma (TBI and SCI), stroke, and Parkinson’s disease. The inflammatory burden initiated by injury/disease is further increased by free toxic iron derived from micro-bleeds which is known to act as a powerful promoter of chronic inflammation. Focus has been given to cellular and molecular neurobiology related to the therapies-induced recovery of disabilities (spasticity/rigidity-motor, anxiety-like behavior, cognitive, balance, and pain problems). The long-term focus of my laboratory research has been to understand the molecular-physiological-through-imagining (MRI)-behavioral neurobiology of motor, sensory and cognitive plasticity following pharmacotherapy and neurorehabilitation using preclinical (rodent) models of neurotrauma (spinal cord, traumatic brain injuries, and stroke), and neurodegenerative/neuro-autoimmune diseases (e.g., PD, MS, ALS). Research focus has been directed to mechanism-based research studies that involve the development and testing of innovative translational targeted pharmacological therapies in conjunction with other complementary therapies (e.g., programmed locomotor exercise, transcranial magnetic stimulation, electrical stimulation on acupuncture points, stem cell and gene therapy) aimed at inducing guided neuroplasticity and neuroregeneration, and ultimately reducing disabilities. Drug toxicological studies using behavioral, physiological, and histological measures are an integral part of this therapeutic initiative.

The research program in the Bose Laboratory is supported by funding from the US Department of Veterans Affairs (the list is not included here under the funding subheading), the Department of Defense (DoD), NIH, and several other funding agencies.

• Advanced MRI and stroke
• Post-Traumatic Stress Disorder
• Stroke
• Traumatic spinal cord injury
• traumatic brain injury

0000-0002-1378-3644