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Ketamine

*Please take the quiz below the video to receive credit.

Objectives

Explain the pharmacokinetic and pharmacodynamic rationale behind ketamine use in critically ill patients.
Discuss the evidence behind ketamine for sedation and pain across critically ill populations.
Define recommendations for ketamine use and limitations for its use based upon current evidence.

Articles

Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review
The Use of Intravenous Infusion or Single Dose of Low-Dose Ketamine for Postoperative Analgesia: A Review of the Current Literature

Lecture

Quiz

Ketamine Quiz

Name*
First Last
1. Which of the following is the correct elimination half-life of ketamine?*
- a. 2-3 hrs
- b. 4-6 hrs
- c. 1 hr
- d. 8-10 hrs
2. What hemodynamic effects did Christ, et al. 1997 discover regarding ketamine?*
- a. Increased CI, decreased MAP, decreased PWP, decreased SVR
- b. Decreased CI , increased MAP, increased PCWP, and increased SVR
- c. Increased CI, decreased CVP, increased PAP, decreased SVR
- d. No change in hemodynamic effects
3. Which of the following are considered limitations to the use of ketamine?*
- a. Hypotension
- b. psychometric potential
- c. increased ICP
- d. Both B and C
- e. None of the above
5. True or False: Adverse effects of ketamine include tachyarrhythmias, psychologic disturbances, and hallucinations.*
- True
- False
6. Which of the following correctly represents the onset of ketamine?*
- a. 10 to 20 seconds
- b. 30 to 40 seconds
- c. 60 seconds to 2 minutes
- d. 40 seconds to 60 seconds
7. True or False: Ketamine exerts it effects on the NMDA receptor in the brain.*
- True
- False
8. True or False: Ketamine should be use as a solo therapy for both sedation and analgesic effects.*
- True
- False
9. Has ketamine been shown to reduce the amount of opioids required to adequate treat pain in the post-operative patient population?*
- Yes
- No
10. Which of the following medications have not been shown to cause hypotension in the post operative population?*
- a. Versed
- b. Fentanyl
- c. Ketamine
- d. Propofol

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