C. Diff Colitis Lecture *Please take the quiz below the video to receive credit. Quiz C. Diff Colitis Presentation Questions Name* First Last 1. Which of the following best describes Clostridioides difficile?* A. Gram-negative, spore forming anaerobe B. Gram-positive, spore forming anaerobe C. Gram-positive, non-spore forming aerobe D. Gram-negative, non-spore forming anaerobe 2. What is the most significant risk factor for developing CDI?* A. Proton pump inhibitor use B. Advanced age C. Recent gastrointestinal surgery D. Antibiotic exposure 3. Which toxins are responsible for the pathogenicity of C. difficile?* A. Exotoxins A & B B. Endotoxin and cytotoxin C. Lipopolysaccharide and enterotoxin D. Hemolysin and shiga toxin 4. Hypervirulent strains of C. difficile (BI/NAP1/027) are associated with which feature?* A. Lack of spore production B. Resistance to cephalosporins only C. Overproduction of toxins A & B and fluoroquinolone resistance D. Absence of toxin B production 5. Which of the following is the first-line treatment for initial episode of CDI?* A. IV Metronidazole B. Oral Vancomycin or Fidaxomicin C. Oral Metronidazole only D. Rectal Vancomycin 6. Which diagnostic test is highly sensitive and specific but cannot distinguish colonization from active infection?* A. GDH Antigen EIA B. NAAT (PCR for toxin gene) C. Toxin A & B EIA D. Cell cytotoxicity assay 7. A patient presents with WBC 55,000, lactate 6 mmol/L, hypotension, and ileus. This presentation is most consistent with:* A. Mild CDI B. Severe CDI C. Fulminant CDI D. Asymptomatic colonization 8. Which of the following is the recommended management for fulminant CDI?* A. Oral Fidaxomicin monotherapy B. Oral Vancomycin 500mg QID + IV Metronidazole ± Rectal Vancomycin C. Oral Metronidazole 500mg TID D. IV Vancomycin alone 9. Fecal microbiota transplantation (FMT) is primarily indicated for:* A. Initial CDI B. Severe CDI C. Multiple recurrences of CDI D. Fulminant CDI with shock 10. Which of the following prevention strategies is NOT effective against C. difficile transmission?* A. Handwashing with soap and water B. Contact precautions with gloves and gowns C. Alcohol-based hand sanitizers D. Environmental cleaning with sporicidal agents
