Martynyuk Laboratory: Neurosciences in Anesthesiology
Professor of Anesthesiology and Neuroscience
Member of the McKnight Brain Institute
Lab: MSB 526
Office: MSB 526F
Primary Research Interests
Welcome to Anatoly Martynyuk’s Lab! Our research, which is funded by the NIH, focuses on the mechanisms of developmental effects of neonatal anesthesia.
Human and especially animal studies suggest that exposure to general anesthesia during the early postnatal period leads to long-term neurocognitive abnormalities. Poor understanding of the full range of body systems affected by anesthetics and the underlying mechanisms are major road blocks to the development of safer anesthesia. Thus far, the search for neonatal anesthesia-induced abnormalities has been limited to the brain.
The results of our studies provide evidence that sevoflurane, the most frequently used anesthetic in pediatric patients, and propofol, the most frequently used intravenous anesthetic, when administered to neonatal rats result in an acute increase in serum levels of corticosteroids and in exacerbated endocrine activity in adulthood when at rest and in responses to stress, as well as in neurobehavioral abnormalities. These long-term abnormalities are more prominent in male rats. Examples of our findings can be seen by clicking on the following hyperlinks.
We test the hypothesis that anesthetic-enhanced activity of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis and γ-aminobutyric acid type A receptor-mediated depolarization/excitation may play a mechanistic role.
Other Research Interests
- Mechanisms of brain dysfunction in phenylketonuria
- Therapeutic applications of antiglutamatergic agents with polyvalent action and moderate potency for treatment of neurological and neurocognitive disorders
Faculty involved in our research
Join the team!
We welcome undergraduate/graduate students, post-doctoral fellows, residents, and faculty who would like to contribute to our research.
We are looking for postdoctoral fellows with prior experience with slice electrophysiology and/or rodent behavioral techniques. Please forward your CV to Dr. Anatoly Martynyuk (firstname.lastname@example.org).